Dr. John Cush RheumNow
2 years 4 months ago
SLE Preview: abolishing refractory with CAR-T and better B-cell therapies
Despite advancements, some SLE patients remain refractory to belimumab and off-label rituximab, the main B cell-targeted therapies in the last 15 years.
https://t.co/778buNUq1C https://t.co/4ub8VbrLb6
With a better understanding of pathophysiology, improved management guidelines, available medications, and a multidisciplinary approach, pregnancy for lupus patients has become more feasible. Despite these improvements, some patients still experience poor outcomes, highlighting the need for biomarkers that can predict these risks. An abstract presented at #EULAR2024 (POS1393) explored this possibility.
Mrinalini Dey DrMiniDey
2 years 4 months ago
📄 You can now read my article on #CardiovascularDisease, #Stroke & #Mortality @RheumNow!
🌟 Featuring 2 cohort studies from @MayoClinic, presented at #EULAR2024
🔗 https://t.co/b639vE5hSA
@MyasoedovaElena
Md Yuzaiful Md Yusof Yuz6Yusof
2 years 4 months ago
#EULAR2024 OP0193 Watch out, blinatumomab will BiTE! Bi-specific T-cell engagers (BiTEs), kill Bcells by engaging Tcells. In 6 refractory #RA patients (failed 3 x ts/bDMARDs), deep blood & tissue depletion were met, good response. Brief raised temp but no cytokine storm @RheumNow https://t.co/OmxSbTXfZq
David Liew drdavidliew
2 years 4 months ago
Fascinating - @ndb_org installed an app to measure smartphone usage, and texting less and moving less were associated with more flares.
The pseudo-wearable in our pockets??
#EULAR2024 POS0678 @RheumNow https://t.co/ZA0hd3Q10d
Aurelie Najm AurelieRheumo
2 years 4 months ago
Is muscle US useful in RA?
100+ pts 1yr followup
BL muscle thickness correlated w/ grip strength improvement
HAQ improv correlated w/ pennation angle vastus lateralis
No diff between muscle morphology & DAS
I'd say it's still easier to US joints!
@RheumNow #EULAR2024 POS1033
David Liew drdavidliew
2 years 4 months ago
RA patients on abatacept have an appalling immunogenic response to Shingrix. Humoral fades away in the first year, and an absence of cellular responses.
Alarming and need strategies to combat this #EULAR2024 POS0620 Winthrop/@RADoctor @RheumNow https://t.co/8gY9ocLBDp
David Liew drdavidliew
2 years 4 months ago
If your GCA flares, do you get the same features as you did at diagnosis?
20% of the time it can be new, so keep on doing the checklist!
(also, visual flares uncommon - the power of pred)
#EULAR2024 POS0110 @MayoClinic @MdWarrington @RheumNow https://t.co/hkF8vJT6HI
Md Yuzaiful Md Yusof Yuz6Yusof
2 years 4 months ago
#EULAR2024 POS0390 What impact of regulatory warning on JAK-i on access to therapy? Data from UK BSSR-BR reported 4 in 5 #RA patients would have been considered ‘high-risk’. Of these, 28% had failed ≥3 biologics; so no suitable alternatives. Enormously impacted @RheumNow https://t.co/XeS9qHXSpH
David Liew drdavidliew
2 years 4 months ago
What psychosocial factors drive treatment outcomes and disease activity for people living with rheumatoid arthritis?
#EULAR2024 POS0309-PARE @DrMiniDey @ElenaNikiUK @RheumNow https://t.co/q0tTLSL044
Dr. Antoni Chan synovialjoints
2 years 4 months ago
Join me on @RheumNow at 6pm this evening here in Vienna to hear about the roundup from today at #EULAR2024
Aurelie Najm AurelieRheumo
2 years 4 months ago
Do we give enough attention to pts mental health?
2 cohort 400+ RA tREACH & DEPAR 500+ PsA
RA 20% depression 30% anxiety
PsA 19% depression 22% anxiety
2 yrs no remission
RA OR 2.5 depression OR 1.7 anxiety
PsA OR 6.10 depression OR 4.67 anxiety
@RheumNow #EULAR2024 POS0946 https://t.co/ok4HRNJqgY
