The majority of practicing rheumatologists at RheumNow Live were unaware of the new ACR guidelines issued in 2022 regarding dietary and lifestyle recommendations for patients with Rheumatoid Arthritis. Dr. Monica Guma reviewed these guidelines during her lecture on the impact of diet on disease activity and therapeutic response.
Interstitial lung disease (ILD) is the most widespread and fatal pulmonary complication of rheumatoid arthritis (RA). A recent metanalysis shows the pooled prevalence of RA-ILD was approximately 18.7%. This systematic review included 56 studies with 11,851 RA-ILD patients. The overall prevalence of RA-ILD was 18.7% (95% CI 15.8-21.6).Prevalent RA-ILD was associated with several risk factors:
The central dogma proposed that genetic information predominantly transfers from DNA to RNA during gene expression to make a functional product protein. This absolute theory has been debunked because of the influence of the environment on how genes are transcribed.
Dr. John Cush RheumNow
2 years 4 months ago
Quote: ""I got the message. All of us get the message, sooner or later. If you get it before it's too late or before you're too old, you'll pull through all right." ~ Nat King Cole https://t.co/dtGqztmJie
Annals of the Rheumatic Diseases ARD_BMJ
2 years 4 months ago
Should all patients with #polymyalgia rheumatics be screened for #giantcellarteriitis with vascular #ultrasound? A recent viewpoint summarizes the evidence:
đź“Šprevalence of subclinical GCA may be as high as 25%
https://t.co/UL6gWRdE5R https://t.co/EAlRyNNWYt
Dr. John Cush RheumNow
2 years 4 months ago
Cohort of 158 active #RA pts (DAS28 3.6-5.6 & pain 4-7/10) found that Pain was explained by:
- 27% - Inflammation (+PDUS), no FM
- 27% - w/ FM
- 19% - w/ both FM and inflamm
- 27% (No FM, no PD) - peripheral nociceptive pain https://t.co/uM6Gw8D8D8 https://t.co/Lk0ylcBDvM
Dr. John Cush RheumNow
2 years 4 months ago
Systemic Score Predicts Still's Disease Severe Complications
A multinational study of adults with Still's disease found that calculating their systemic score at baseline significantly predicted the patients risk for life-threatening outcomes.
https://t.co/YB7EcWFruE https://t.co/Vcql5tZHOk
Dr. John Cush RheumNow
2 years 4 months ago
Research on SGLT2 inhibitors in #gout is needed. They have been shown to reduce uric acid & gout flares, and may be uricosuric or be antiinflammatory. Also decreased incident gout (by half) among at-risk patients with type 2 diabetes (HR 0.54) https://t.co/CGG9aFsgoD https://t.co/5O2f3MFL8C
Dr. John Cush RheumNow
2 years 4 months ago
Korean claims study of #RA & pregnancy (& adverse preg outcomes (APO), shows MTX or LEF use w/in 3 mos of conception assoc w/ incr. in APOs (aOR 2.14-.68). In 5728 preg: 1152 APOs, HCQ most commonly used, DMARD use decreased during preg. https://t.co/7UBsNdpRgx https://t.co/cY1N73FG8Q
Dr. John Cush RheumNow
2 years 4 months ago
Korean biologics registry study 526 Ank Spondylitis pts on TNFi > 1yr and tapered; 24.1% experienced flares. Predictors of flare included B27+, inflammatory LBP, psoriasis, SpA Fam Hx, DM, ≥50% TNFi tapering, Dz activity (ASDAS-CRP, BASFI) at tapering https://t.co/jjyMX3borT https://t.co/u0lbtfCyz1
Dr. John Cush RheumNow
2 years 4 months ago
GEM: Dysphagia in myositis pts is from skeletal muscle involvement, causing upper pharyngeal dysphagia, but may also manifest as dysphonia, nasal regurgitation, or aspiration (w/ risk of pneumonia). https://t.co/MOyfdCJywC
Dr. John Cush RheumNow
2 years 4 months ago
Cabaletta Bio announced FDA has granted Orphan Drug Designation to CABA-201, a 4-1BB-containing human CD19-CAR T cell agent, to treat systemic sclerosis. RESET (REstoring SElf-Tolerance) trial program includes the Phase 1/2 RESET-SSc trial https://t.co/Vo5jIHBrPj https://t.co/TXvFypbZdw
Dr. John Cush RheumNow
2 years 4 months ago
Secondary Sjogren’s Ups Rheumatoid Arthritis Severity
A Swiss observational study has shown that RA patients with concomitant Sjögren’s disease (SjD) are more likely to have a severe RA phenotype, and be less responsive to treatment.
https://t.co/4dcackIe4S https://t.co/5VZ9I7r29F
Dr. John Cush RheumNow
2 years 4 months ago
Autoimmune dz pts have higher risk of macular degeneration. Cleveland Clinic study of 200K AMD vs controls, finds:
- SLE (RR 1.73)
- Scleroderma (1.65)
- Psoriasis (1.48)
- Vasculitis (1.48)
- RA (1.4)
- UC &CD (~1.42)
- Sarcoid (1.42) https://t.co/RrXaaqz3Aw https://t.co/9dGoGRCBYu
Dr. John Cush RheumNow
2 years 4 months ago
2023 EULAR Psoriatic Arthritis Recommendations
EULAR has updated its treatment recommendations— The updated guidance includes 7 overarching principles and 11 recommendations regarding treatment strategy and pharmacological therapies.
https://t.co/ja4g5I9emg https://t.co/9pxeup5ACg
