Metanalysis of 26 reports and 195 juvenile Dermatomyositis pts (age 4.9 yrs) treated w/ JAK inhib (tofa, rux, & bari); Good improvement in 90%, 69% & 93%, respectively. JAK indication refractory skin dz (35%) or muscle involvement (29%). TIME FOR RCTs!! https://t.co/Vtm2n9BWV1 https://t.co/1bXZokW1AO

• https://buff.ly/3WJE4NC

Review article of Interstitial Lung Dz Assoc w/ Systemic Sclerosis. SSc-ILD prevalence ranges 25-95%; ILD is a main cause of morbidity and mortality, contributing to 35% of deaths https://t.co/8mMFbDu4gi https://t.co/nQ4GfNcMWt

• https://buff.ly/3WH5Om7

Alot of murky "research" on Platelet-rich plasma (PRP). This RCT of120 pts having anterior cruciate ligament reconstruction (half randomized to PRP) shows no PRP benefit, no significant improvement of knee symptoms & function post ACLR https://t.co/AwkCAq1QFb https://t.co/YP0hJd7soc

• Intra-Articular Platelet-Rich Injection After ACL Reconstruction

Retrospective cohort study compared 5825 #AS pts vs 28,356 matched controls; showed an increased risk of pulmonary embolism w/ AS; not present pre-Dx ((0.4% vs 0.2%), but incr post-AS Dx (PE IR 11.6 vs 6.8/10KPY: adj HR 1.70;; p<0.001) https://t.co/wSkAMozvnL https://t.co/5Q470QkAxe

• Increased Risk for Pulmonary Embolism among Patients with Ankylosing Spondyliti…

K Kuhn et al: Altered tryptophan catabolism by microbiome may contribute to inflammatory arthritis. Tryptophan increases indole leading to ncreases in serum IL-6, TNF, and IL-1β; splenic RORγt+CD4+ T cells, & IL-23 and IL-17 production https://t.co/i9le12QZm2 https://t.co/akeXxWnQ9o

• Microbiota-dependent indole production stimulates the development of collagen-i…

Substitute Measures of Inflammation (many dervied from the CBC) https://t.co/b2AuVERJQn https://t.co/QXZ8GthsMW

• Substitute Inflammatory Measures | RheumNow

My Cancelled Lecture Slides Listen to last week's podcast for more context! https://t.co/C3bm2psfxZ https://t.co/sjIgDiVKtK

• My Cancelled Lecture Slides | RheumNow

Infectious Mortality in ARD Infectious conditions are a significant cause of mortality in ARD. Among patients hospitalized with an infection, we compared in-hospital and long-term (3-year) mortality between those with and without ARD. https://t.co/p4n5Los89F https://t.co/vUBLC9TDDG

• Infectious Mortality in Autoimmune Rheumatic Disorders | RheumNow

Save the date! We’ll be covering #EULAR24! https://t.co/HGjP2SFyOp

Small-molecule Drugs to Treat Systemic Lupus Erythematosus A metanalysis of randomized controlled trials (RCTs) on treatments of systemic lupus erythematosus (SLE), confirm the efficacy of several targeted small-molecule drugs. https://t.co/ZYPZcfKrBD https://t.co/ZGYFNVgN0s

• Small-molecule Drugs to Treat Systemic Lupus Erythematosus | RheumNow

A unique study in military medicine of 1.5 million ED visits reveals the dynamics of high-rank and high-power patients and doctors, and the care they get/provide https://t.co/hbsUt1s9YR @ScienceMagazine @sdschwab @vini_singh_ https://t.co/RIjq4awgeR

• How power shapes behavior: Evidence from physicians
• https://twitter.com/EricTopol/status/1791172694081405244/photo/1
• https://twitter.com/EricTopol/status/1791172694081405244/photo/1

Interferons and Lupus Subsets In a new study, researchers from Johns Hopkins Medicine say they have uncovered insights as to the relationship between interferons and lupus, which affects up to 1.5 million Americans. https://t.co/eWnNqVUpK9 https://t.co/yNp4GYHYKu

• Interferons and Lupus Subsets | RheumNow

Risk Factors for Hydroxychloroquine Retinopathy A long-term hydroxychloroquine users study found that 2.7% developed retinopathy, and identified risk factors as increasing age, female sex, chronic kidney disease stage 3+ and tamoxifen use. https://t.co/3HWWoCMXfI https://t.co/TuYgzRJEzR

• Risk Factors for Hydroxychloroquine Retinopathy | RheumNow