Dr. John Cush RheumNow
2 years 5 months ago
PAPA (pyogenic arthritis, pyoderma gangrenosum & acne) syndrome is a hereditary autoinflammatory Dz caused by dominant mutation in PSTPIP1 (triggers IFN-γ-mediated pyrin induction & IL-18 release; can be Tx by JAK inhibition) https://t.co/fy0MnwDA5U https://t.co/l8n2EwgV0t
Dr. John Cush RheumNow
2 years 5 months ago
FDA approves 10th adalimumab biosimilar - called Simlandi (adalimumab-ryvk), from Alvotech and Teva. Unique in that it's the 1st high-concentration, citrate-free & interchangeable ADA biosimilar.https://t.co/V6zbCnpfvn https://t.co/igLddGMcoM
Dr. John Cush RheumNow
2 years 5 months ago
Norway study 1558 chart-reviewed SLE cases; 797 were new-onset SLE from 1999 to 2017. During this period the annual SLE incidence rates fell; mostly pronounced in women 50-59 yrs (fell 3.4 to 1.1 per 100K) - paralleled by 74% reduction menopausal HRT https://t.co/zYkXAnEcOI https://t.co/oaz9t65zZy
The common inflammatory condition sinusitis is linked to a 40% heightened risk of a subsequent diagnosis of rheumatic disease, particularly in the 5 to 10 years preceding the start of symptoms, finds research published in the open access journal RMD Open.
Dr. John Cush RheumNow
2 years 5 months ago
Australian study shows self-reported difficulties w/ ambulation (limited<=1 km) had a higher risk of hip and spinal fractures (32% to 219% more)/ Included 239 000 adults >45 yrs https://t.co/IWvKmPc2t8 https://t.co/CDYDzhMUoa
Dr. John Cush RheumNow
2 years 5 months ago
When Meningitis Strikes Twice
Amanda Moyer, MD, presents her poster at RWCS 2024.
https://t.co/er2E2XnrZZ https://t.co/vwDopOLPRH
Dr. John Cush RheumNow
2 years 5 months ago
With New Medications Come New Myopathies
Alexia Hwang, MD, presents her poster at RWCS 2024.
https://t.co/BjYxKk2QlW https://t.co/vDA0dllMQz
Dr. John Cush RheumNow
2 years 5 months ago
Immunosuppression Increasing
Dr. Jack Cush reviews the news and journal reports from the past 2 weeks on https://t.co/V10S4oVFsv; but begins with a discussion of what constitutes "immunosuppression" and how it applies to our patients.
https://t.co/KvZIiKowox https://t.co/cbBYydVQbB
Dr. John Cush RheumNow
2 years 5 months ago
Single center study of 163 pts (mostly RA) Rx w/ tocilizumab found 41 hospitalized & 49% for serious infx. SIE were more common w/ eosinopenia (EC < 0.05 g/L; avg (0.06 vs 0.20 g/L) & low ratio EC/NC ratio (× 1000 < 11.8) (median (6.54 vs 48.50). https://t.co/88sbHBIhXt https://t.co/6wUeqSbVxx
Dr. John Cush RheumNow
2 years 5 months ago
No clear link between weather & MSK symptoms
There is a belief that changes in weather conditions, such as impending rain or temperature, can trigger or worsen muscle and joint pain but Australian researchers have found no clear pattern between the two.
https://t.co/V3rfCTWRBQ https://t.co/eFdZH4LoNA
A multicenter, double-blind, phase 3, randomized, active-controlled trial has shown that Benralizumab (BEN) was noninferior to mepolizumab (MEP) for the induction of remission of patients with relapsing or refractory Eosinophilic granulomatosis with polyangiitis (EGPA).
Dr. John Cush RheumNow
2 years 5 months ago
CD19 CAR T-Cell Therapy in Autoimmune Disease
The NEJM has published the results of CD19 B cell depletion (by CAR-T cell therapy) in autoimmune disease patients, demonstrating it to be feasible, safe, and efficacious.
https://t.co/ym3pAsI5Sf https://t.co/AnfKOISscV
A comprehensive overview of Behcet's syndrome appeared in last week's NEJM, reviewing the numerous advances in the immunogenetics, syndrome recognition, and targeted therapeutic approaches. Despite certain advances, there remains a need for better clinical trials, better diagnostic tools, and biologic treatments to afford better outcomes.

