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Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. This week we discuss hipsters undergoing hip replacement, pregnancy outcomes in RA and the future of academic clinicians.
Outcomes of Acute, Subacute and Persistent Low Back Pain

Low back pain is a major cause of disability around the globe,

Dr. John Cush RheumNow

2 years 6 months ago
Outcomes of Acute, Subacute and Persistent Low Back Pain Low back pain is a major cause of disability around the globe, with more than 570 million people affected. https://t.co/aIR110aEr0 https://t.co/tKPp0Un68H
Is non-alcoholic fatty liver dz assoc w/ osteoarthritis? Study of 2633 pts - 317 (12.8%) w/ OA& 1140 NAFLD(41.5%);

Dr. John Cush RheumNow

2 years 6 months ago
Is non-alcoholic fatty liver dz assoc w/ osteoarthritis? Study of 2633 pts - 317 (12.8%) w/ OA& 1140 NAFLD(41.5%); NAFLD was positively correlated with OA (OR = 1.72; 1.26–2.34). https://t.co/whWX2XIu3d https://t.co/sGXQYSFcH3
Wed. Jan 31st was Dr. Janet Woodcock’s last day at the US Food and Drug Administration (FDA), capping a remarkable 38-

Dr. John Cush RheumNow

2 years 6 months ago
Wed. Jan 31st was Dr. Janet Woodcock’s last day at the US Food and Drug Administration (FDA), capping a remarkable 38-year career. A rheumatologist, Dr. Woodcock She’s has been one of the most powerful and influential drug regulators worldwide. THANKS JW! https://t.co/vVUGaknYmM https://t.co/9pV7QYH0zm
Somewhere between 24 and 50 million Americans have an autoimmune disease, a condition in which the immune system attacks our own tissues. As many as 4 out of 5 of those people are women. Rheumatoid arthritis, multiple sclerosis and scleroderma are examples of autoimmune disorders marked by lopsided female-to-male ratios. The ratio for lupus is 9 to 1; for Sjogren’s syndrome, it’s 19 to 1.
Full read, great review of JAK/STAT signaling and JAK inhibitors published in Ann Rheum Dis.-- Selectivity, efficacy and

Dr. John Cush RheumNow

2 years 6 months ago
Full read, great review of JAK/STAT signaling and JAK inhibitors published in Ann Rheum Dis.-- Selectivity, efficacy and safety of JAKinibs: new evidence for a still evolving story (Authored by JAK mavens) https://t.co/dimQAy2igo https://t.co/5xh1DqjFxN
US commercial insurance claim analysis of laboratory screening and monitoring practices in chronic inflammatory skin disease (CISD) patients shows that < 60% received the recommended pretreatment testing when starting systemic immunomodulatory treatment.
A cross-sectional survey of academic physicians shows that approximately one-third intend to leave their institutions in the next two years. Burnout, lack of professional fulfillment, and other personal and organizational factors were associated with intention to leave. A survey was adminstered to 37 511 attending-level medical specialists at 15 academic medical institutions between May 2022 to March 2023.
Diet and Osteoarthritis Pain

Knee osteoarthritis (OA) pain was worse with a pro-inflammatory diet, an observational st

Dr. John Cush RheumNow

2 years 6 months ago
Diet and Osteoarthritis Pain Knee osteoarthritis (OA) pain was worse with a pro-inflammatory diet, an observational study suggested. https://t.co/GHSd9SzNav https://t.co/MiCj9gE4Kj
Aging Brain Increases Pain in Older Women
  • EurekAlert!
A new study has found that the brain system enabling us to inhibit our own pain changes with age, and that gender-based differences in those changes may lead females to be more sensitive to moderate pain than males as older adults.
240 consecutive estab. RA pts underwent cervical spine X-rays looking for ant. atlantoaxial subluxation (aAAS >3 mm)

Dr. John Cush RheumNow

2 years 6 months ago
240 consecutive estab. RA pts underwent cervical spine X-rays looking for ant. atlantoaxial subluxation (aAAS >3 mm); aAAS found in 25 (10.4%) mean interval =4.2mm. One-third had no neck pain. aAAS predicted by lower BMI, CCP, erosions & joint prostheses https://t.co/OXNbJ6aiCG https://t.co/4tNqGvfNcK
Dupilumab (IL-4/13 Inhib) may cause MSK Sxs. Study of 470 Atopic Dermatitis pts on dupilumab; 36 referred to rheum cons

Dr. John Cush RheumNow

2 years 6 months ago
Dupilumab (IL-4/13 Inhib) may cause MSK Sxs. Study of 470 Atopic Dermatitis pts on dupilumab; 36 referred to rheum consult, 26 pts (14M/12F) had US/MRI proven enthesitis, arthritis, or tenosynovitis (16 mild, 4 severe). All responded to NSAID or DUP D/C https://t.co/S3ACOC4xUZ https://t.co/juAYbIxNZ6
Metabolic Syndrome increases RA risk. UK Biobank (369,065) study saw 4901 incident RA (12 yrs F/U). Signif hi RA risk wi

Dr. John Cush RheumNow

2 years 6 months ago
Metabolic Syndrome increases RA risk. UK Biobank (369,065) study saw 4901 incident RA (12 yrs F/U). Signif hi RA risk with MetS (HR 1.22), waist circumf (1.21), incr TG (1.12), decr HDL (1.31) & hyperglycemia (1.15) - all additive. https://t.co/jN15axxTmu https://t.co/DP5bFwOB3F
Ultrasound subclinical synovitis is found in a third of individuals at risk of rheumatoid arthritis (RA) patients; in half of these, subclinical synovitis resolves with a favorable outcome.
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