CRUS-SURC CrusSurc
2 years 6 months ago
#RNL2024 @RheumNow SPA spectrum Q and A 🔥 - @lihi_eder 👏advocating for #POCUS #mskus and enthesitis - we agree @CrusSurc - confirming the concept of #pocus as an extension of the clinical exam and to be kept in the hands of the clinician - doesn't seem an area yet for AI 🤖
Richard Conway RichardPAConway
2 years 6 months ago
Oh, snap! But this is true, a single course rituximab at baseline and none at 6 months (or anything else) as a comparator is just wild in a 12 month trial @EBRheum @RheumNow #RNL2024 https://t.co/wuIkuLzIpg
Richard Conway RichardPAConway
2 years 6 months ago
A picture paints a thousand words. One of the reasons why statistical significance is not the be all and end all. I would say severe DAH is the most likely scenario I would use PLEX, more so than severe renal disease. @EBRheum @RheumNow #RNL2024 https://t.co/GHg6t4OHxf
Richard Conway RichardPAConway
2 years 6 months ago
Rituximab is superior to cyclophosphamide in relapsing AAV. Provided you are relapsing after having cyclophosphamide as your first agent of course... @EBRheum @RheumNow #RNL2024 https://t.co/JfbcKH2zCG
Eric Dein ericdeinmd
2 years 6 months ago
Does adding NSAID to TNFi help prevent radiographic progression?
@LianneGensler
#RNL2024 @RheumNow
Adding Celecoxib to TNFi: numerically less progression, but not statistically significant https://t.co/rzuOL9q93x
Dr. Rachel Tate uptoTate
2 years 6 months ago
Dr. @lihi_eder approaches enthesitis both clinically and with imaging *highly recommended.
NSAIDs and local steroids may be useful with caution. Advanced tx strongly recommended if initial tx fails/other domains involved.
#RNL2024 @RheumNow https://t.co/SKrWmp115M
Eric Dein ericdeinmd
2 years 6 months ago
Vedolizumab-induced enthesitis
@lihi_eder #RNL2024 @RheumNow
11/90 (12.2%) of pts on VDZ for IBD w/ develop new-onset enthesitis
Is this true drug rxn or previously masked by prior meds (TNF)?
Usually unilateral +/- oligo, dactylitis
Most respond to NSAID or injxn, 27% change Rx
Eric Dein ericdeinmd
2 years 6 months ago
Enthesitis @lihi_eder
@RheumNow #RNL2024
- NSAID - 1st line in mild/isolated
- GC injxn but caution at Achilles
- MTX cond rec by GRAPPA (SEAM PsA)
- All bDMARD work vs PBO (TNFi, IL17, 12/23, 23, JAK, PDE4) - none superior
- IL17 v ADA: higher resol for IXE v ADA, but mixed data https://t.co/20KnQo4kpq
Richard Conway RichardPAConway
2 years 6 months ago
Advanced therapies in enthesitis. Don't believe the spin, they all work, no clear evidence that any agent is better than others. @lihi_eder @RheumNow #RNL2024 https://t.co/FwLMUmmClB
Dr. Rachel Tate uptoTate
2 years 6 months ago
@JointMD updates us on nomenclature. "AS" is out and "AxSpA" is in.
#RNL2024 @RheumNow https://t.co/gdmZeuMNpW
Eric Dein ericdeinmd
2 years 6 months ago
#RNL2024 @RheumNow
@lihi_eder on enthesitis
- ~1/3 PsA, SpA
- Enthesitis precedes onset of PsA in PsO, high u/s score ass. w/ RFs (BMI, nail dyst)
- Exam: tenderness (non-specific), as swelling uncommon. U/s helpful, but non-specif
- Marker of severity, higher risk of damage
Dr. Rachel Tate uptoTate
2 years 6 months ago
Dr. @lihi_eder recommends enthesial evaluation with POC ultrasound if available in addition to her clinical evaluation. #RNL2024
@RheumNow https://t.co/LQiyFK5VB1
Nouf Al hemmadi NoufAhmedAlham2
2 years 6 months ago
Goodbye AS.
Eric Ruderman
#RNL2024
@RheumNow https://t.co/FThKwuP3M6
Dr. Rachel Tate uptoTate
2 years 6 months ago
Enthesitis precedes the onset of PsA in PsO patients. Dr. @lihi_eder discusses the importance of US in evaluation of these patients.
#RNL2024 @RheumNow https://t.co/bPLR7zpNe2
Dr. Rachel Tate uptoTate
2 years 6 months ago
Thank you to all of the excellent #RNL2024 speakers!
@Bweber04, Dr. Monica Guma, Dr. Hani Gabalawy, Dr. Connie Weyand, Dr. Lisa Stamp, @AlexisOgdie, @_AprilArmstrong, @lihi_eder, @JointMD, Dr. Kevin Winthrop, Dr. Bruce Strober, @BharatKumarMD, Dr. David Karp, @Kahlenberglab,… https://t.co/f6gzCwe7Xb https://t.co/2SY9mPqdkO
