Data from the Global Burden of Diseases Study 2019, suggests that early-onset osteoarthritis (OA) (before age 55 yrs) is an emerging health issue that parallels societal problems of obesity. 

Having patients waiting for knee arthroplasty undergo a preoperative program of weight loss, exercise, and other interventions gave them modestly improved pain, function, and quality of life, a small randomized trial showed.

In patients with clinically stable systemic lupus erythematosus (SLE) and lupus nephritis, the withdrawal of mycophenolate mofetil was not significantly inferior to mycophenolate maintenance, but MMF withdrawal had numerically more reactivations, while MMF maintenance had more infections.Because of its teratogenicity, cost and side effects it is unknown if disease quiescence is reason enough to withdraw mycophenolate.

Annals of Internal Medicine reports a large, binational study finding SARS-CoV-2 infection was associated with an increased risk for autoimmune inflammatory rheumatic diseases (AIRDs) that extends up to 12 months after infection. Moreover, vaccination showed some protection against AIRDs, depending on severity of infection.