Dr. John Cush RheumNow
2 years 9 months ago
Do I have Arthritis?
How I handle this frequent curbside consult question...
https://t.co/uX6MUfy59w https://t.co/kYviOhcLQj
Dr. John Cush RheumNow
2 years 9 months ago
Metanalysis of CNS Lupus, 44 studies, 17 865 early- (<50y) vs 2970 late-onset SLE (>50y) pts. CNS LE in 16%, more common in younger LE (OR: 1.41). Early-LE had more seizures (OR: 1.68), psychosis (OR: 1.72). Older - more Peripheral neuropathy (OR: 0.64) https://t.co/XoJjIH69t6 https://t.co/sRyV7A07gA
Dr. John Cush RheumNow
2 years 9 months ago
Biomarker Predicts Survival in Autoimmune Lung Disease
One major subgroup of patients with ILD arising from polymyositis/dermatomyositis (PM/DM) survived significantly longer when serum levels of interferon-λ3 were relatively low, researchers found.
https://t.co/9c9DjOIeoI https://t.co/fBpvjODybd
Dr. John Cush RheumNow
2 years 9 months ago
In Norway incidence of #SLE is decreasing, esp in women 50-59 years. Population study of 1558 confirmed SLE; 797 had new-onset betw 1999-2017. In older women 50-59 yrs incidence fell 3.4 to 1.1/100K (also 74% reduction in menopausal HRT https://t.co/Z1falNwLlD https://t.co/bJ3cXKueKg
Dr. John Cush RheumNow
2 years 9 months ago
Small study of 33 #AAV pts and 21 controls shows nailfold capillaroscopy of no value in diagnosing/assessing AAV pts. https://t.co/uRFDBbLVJq https://t.co/pVETSFlBsp
Dr. John Cush RheumNow
2 years 9 months ago
Poorly documented Dz activity in SpA. AI EHR analysis of 3 Hospitals found 758 pts (328 axSpA, 365 PsA, 65 non-classified SpA). Only 35% axSpA had ASDAS or BASDAI. DAPSA or DAS-28 in only 17% PsA. TJC/SJC in ~20% axSpA & ~32% of PsA https://t.co/OrLdK5k2lN https://t.co/bKjancBG4r
Dr. John Cush RheumNow
2 years 9 months ago
Wallace et al. Dose, duration, recency dependent relationship between GC and MACE. Even 5mg/day, 30 day use, and use 1 year prior associated with risk. 5mg, 7.5mg, 10mg pred for 90 days - 13%, 19%, 27% MACE increase Abstr#2430 #ACR23 #ACRbest
https://t.co/zJ9583vllj https://t.co/M1oKAcnqSH
Curcumin is widely used in traditional Chinese medicine to treat arthritis and is presumed to have analgesic and antiinflammatory effects that may benefit those with osteoarthritis, particularly knee osteoarthritis (KOA).
A network metanalysis was performed to gauge the efficacy and safety of curcumin, both alone and in combination with other drugs (eg, NSAIDs), in the treatment of KOA.
A clinical trial has shown that obese gout patients will benefit from diet and lowered body weight, but weight loss was not associated with beneficial effects on serum urica acid (SUA), fatigue or pain.
Weight loss is commonly recommended as management strategy for gout patients. This trial investigated the effect of an intensive dietary intervention on body weight and gout outcomes in patients with obesity and gout.
Dr. John Cush RheumNow
2 years 9 months ago
There is a dose, duration and recency-dependent relationship between previous GC use and MACE. GC doses 5mg/day, durations of 30 days, and use one year prior to MACE were all associated with an increased risk of MACE, Wallace B Abst#2430 #ACR23 #ACRBest https://t.co/RdLUvW3W7v https://t.co/CcQXQYwu7J
Dr. John Cush RheumNow
2 years 9 months ago
Marketscan claims data shows Frailty as predictor for serious infxn in RA pts Rx w/ b/tsDMARDs. Among 57,980 RA pts (age 48 yrs), 6% were "frail" - this assoc w/ increased risk of serious infections (aHR 1.5) & inpatient hosp (1.4)https://t.co/cvcqE3KQmV https://t.co/We9uwMdt5Y
Dr. John Cush RheumNow
2 years 9 months ago
Anti-TNF mAbs, JAKi & anti-IL17 Rx appear protective against anterior Uveitis in AxSpA pts. Network Metanalysis of 44 trials, AU IR -TNF mAb: 4.1, ETN: 5.4, IL17i: 2.8, JAKi: 1.5, & placebo: 10.8. AU risk: TNFi < JAKi < IL-17i < ETN << PBO https://t.co/uRYKmtUdsZ https://t.co/5XdBVDfgYV
Dr. John Cush RheumNow
2 years 9 months ago
Chinese Phase 2b RCT of telitacicept (TACI-Fc fusion protein inhibits both BAFF & APRIL) 3 doses vs PBO in 249 active SLE pts. Wk 48 SRI-4 response favored TELI (76% 240 mg, 68% 160 mg, 71% 80 mg vs 34% w/ PBO (all p<0.001) https://t.co/fz4W1le4Db https://t.co/0mTC4gQcdr
Dr. John Cush RheumNow
2 years 9 months ago
Congratulations to Professor Paul Emery OBE on being named CBE: Commander of the Most Excellent Order of the British Empire for his research and advances in rheumatology. He is the Versus Arthritis Professor of Rheumatology, Leeds Institute https://t.co/xeJu05q3q8 https://t.co/VvKmHHf0iv

