IFN 5-gene signature to ID high IFN subsets as biomarkfor DEUC in PAISLEY P2 SLE trial Ab847 #ACR23 @RheumNow IFN 5 gene score - 78% IFN-high pt IFN high ass w SLEDAI-2K, CLASI, PGA, dsDNA, low C3/C4/lmphocyte DEUC reduc IFN 5 gene score in both grps, best clin response in IFN hi https://t.co/WpZHE5z8za

PMR in the #ACR23 @US_FDA new approval update - not something you see every day!! @RheumNow https://t.co/yll3d4AicK

• https://twitter.com/drdavidliew/status/1723858116041642281/photo/1

Ab#0848 @RheumNow #ACR23 Biomarkers to Differentiate Flare from Bacterial Ifn in SLE CD14 and CD64 modest increase in infections v flare, better than IL-6 and MRP8/14 One marker not enough to differentiate, but in combo w/ complements, procal, dsDNA improves composite scores https://t.co/MeMYbkMTQH

The critical mass of biosimilars in the US is surely getting there. My opinion: now it’s time for price competition. Otherwise you have to ask, what was the point of it all? Maybe I’m just a naive foreigner. But US patients deserve better. #ACR23 @US_FDA session @RheumNow https://t.co/enHY6xffMa

Baker et al. Danish registry study. Truncal vagotomy increases risk RA (but not OA), HR 2.62 (95% CI 1.47-4.67). Support for vagus nerve stimulation in RA? Abstr#0836 #ACR23 @RheumNow https://t.co/SbphSMLHc7 https://t.co/93SfyGizLt

Inflammatory reflex suggests role of vagal nerve in inflammation regulation Danish database Truncal vagotomy 2000+ pts matched w/ 22000+ = Increase risk for RA HR 2.6 Not the case for supras elective vagotomy (HR 1) No influence on OA @RheumNow #ACR23 ABST0836 https://t.co/3ThYP1nKTe

Lots of our patients taking CBD products, and they won’t always tell us… but if you don’t ask, you’ll miss the drug-drug interaction that affects the meds we rely on. #ACR23 @US_FDA session @RheumNow https://t.co/Q9UMJiTDkq

The belimumab-rituximab combination has utility in SLE, but it comes at an incremental safety cost. May well be worth it in many of our patients, but very understandable that the @US_FDA label gets further clarification #ACR23 @US_FDA session @RheumNow https://t.co/RwF2wbsrQk

Here's the counterpoint to the previous positive tweet on vagal nerve stimulation in RA. The previously promising data on auricular vagus stimulation falls flat on further study Abstr#0837 #ACR23 @RheumNow https://t.co/APnrPhWA9q https://t.co/adA0H1VETt

This is particularly interesting considering this 👇🏼👇🏼 First RCT of NI auricular vagal nerve stimulation did not meaningfully improve RA disease activity or outcomes. No SAEs Is this supporting the need for other VNS modalities? @RheumNow #ACR23 ABST0837 https://t.co/yFcMPoSc31 https://t.co/G069XwUyAz

Late-Breaking Ph 2b RCT of TAK-279, oral TYK2 Inhib, in Active PsA. ACR20 in 53-54% (30 mg qd) vs 29.2% PBO at wk 12 (p = 0.002). Abst #L12 presented on Tuesday. #ACR23 