David Liew drdavidliew
3 years 3 months ago
Men trying to conceive were prev told to avoid MTX. Another myth busted
Why? Spermatozoa lack the FPGS enzyme responsible for MTX-PG metabolism, the tiny amount of MTX-PG in sperm isn’t active. No quality issues!
OP0224 #EULAR2023 @RheumNow (& @ARD_BMJ https://t.co/SDdoNP12oR)
Janet Pope Janetbirdope
3 years 3 months ago
Early Rx with immunosuppressives doesn’t seem to prevent ILD in #scleroderma ? Chanelling bias as dcSSc get more ILD, esp if active disease but in this side it didn’t make a difference #EULAR2023 @RheumNow OP0239 https://t.co/xt0mtpOpYl
Bella Mehta bella_mehta
3 years 3 months ago
Phase 2b-human Knee #OA MM-II, a novel suspension of empty large multilamellar liposomes dimyristoylphosphatidylcholine (DMPC)and dipalmitoylphosphatidylcholine (DPPC)- upto 6ml IA injection - well tolerated with minimal AE. some effect on WOMAC @rheumnow #EULAR2023 abs#POS0106 https://t.co/MM8jIG5bkP
Dr. John Cush RheumNow
3 years 3 months ago
Watch: Baricitinib in Lupus Nephritis
Dr. Peter Nash reports on abstract OP0053 presented at EULAR 2023 in Milan, Italy.
https://t.co/U9sIkCs7dX https://t.co/MgmVHo7wZo
Bella Mehta bella_mehta
3 years 3 months ago
Erosive #handOA is associated with more pain and more functional impairment than #RA - 10 year duration, which ofcourse has more comorbidities. 138 OA, 379 RA pts. #EULAR2023 @rheumnow abst#POS0103 https://t.co/mP3Nzgmw07
Bella Mehta bella_mehta
3 years 3 months ago
Lots of early pipeline data in lupus at #EULAR2023 mainly in the supplement!
AFIMETORAN dual TLR7/8 ANTAGONIST in lupus mice! Maybe steroid sparing! Abst#AB0132
@RheumNow
Day 2 at the international EULAR Congress meeting is always bigger and busier. There were sessions on JIA therapies, crystal arthritis, novel drugs for SLE and Sjogren's, early RA and preclinical RA interventions, IgG4 disease, osteoporosis and the growth and application of artificial intelligence in medicine and rheumatology.
Bella Mehta bella_mehta
3 years 3 months ago
#lupus Phase 1 data #EULAR2023 humanised, afucosyl IgG1 antibody against CXCR5 – receptor on B cells and bonafide T follicular helper(Tfh) and circulating T follicular helper-like(cTfh) cells – Potent, tolerated and caused depletion of cells in SLE and RA.
Abst#AB0511 @rheumnow
Bella Mehta bella_mehta
3 years 3 months ago
bone complications #SLE – imp to maintain vitamin D levels!
Osteonecrosis of the femoral head (ONFH) and Avascular osteonecrosis (AVN) – total 86 pts – 60 had both ONFN and AVN.
ONFN often b/l more morbidity, raynauds and low vit D compared to AVN
Abst#AB0566#EULAR2023 @rheumnow
Bella Mehta bella_mehta
3 years 3 months ago
Obesity in #AOSD – predicted the development of a chronic disease course and biologic DMARD failure, 139 pts with AOSD- 19% Obese (BMI>30) observational study. abst#AB1503 #EULAR2023 @rheumnow
Bella Mehta bella_mehta
3 years 3 months ago
Pearls in AOSD – from #EULAR2023 Italian study of 64 patients – AOSD/sJIA pts who achieved drug-free remission more often had white blood cells count >15.000/uL at baseline, however those who were treated with cyclosporine likely failed drug free remission. Abst#AB1484 @rheumnow
