Dr. John Cush RheumNow
3 years 9 months ago
NIH has granted $4.7 million to fund OHSU/UAB/UNC scientists to develop Novel 2-Pyrimidone (SRI-42718) Chikungunya antiviral drug. 2022: >360,000 Chikungunya cases w/ 77 deaths (mostly Brazil, India Guatemala) w/ 13 acquired in U.S. https://t.co/5ospHoFBBQ https://t.co/E1WKvdhaUO
Dr. John Cush RheumNow
3 years 9 months ago
Swedish study of 4033 incident RA vs 6485 controls - Exposure to occupational inhalable increased risk ACPA+ RA (OR 1.25). Occupational inhalable agents plus smoking and shared epitope markedly elevated risk (OR 18.22) esp in ACPA+RA https://t.co/4lKLEhkURm https://t.co/HFhz8lMR10
Dr. John Cush RheumNow
3 years 9 months ago
Study of 172 febrile pts w skin rash + arthralgia; 112 Dx w/ #AOSD. Use of a "streamlined diagnostic process (looking @ neutrophilia, hyperferritinemia, high IL-18), shortened Dx time (2 vs 4 wks), earlier Dx and more remissions (85% vs 68%, p < 0.05) https://t.co/MSMq2XLeYA https://t.co/ECKkeVqTIW
Dr. John Cush RheumNow
3 years 9 months ago
Biosimilar Bonanza in 2023
Dr. Jack Cush reviews more than a dozen news and journal articles from this past week on RheumNow
https://t.co/FILyCcSThn https://t.co/kBxzZgs6rM
Dr. John Cush RheumNow
3 years 9 months ago
2022 ACR/EULAR Giant Cell Arteritis Classification Criteria
Giant cell arteritis (GCA) has historically been a clinical diagnosis (visual loss, headache, jaw pain, scalp tenderness, etc) supported by labs and histopathology.
https://t.co/inHKcdXLmD https://t.co/g9v1zWkmRp
Dr. John Cush RheumNow
3 years 9 months ago
Small, open label study of 43 RA pts Rx w/ csDMARDs randomized to denosumab or PBO x 24 weeks. Erosions of MCP 2,3 assessed by HR-pQCT shows no significant differences in erosions or safety signals at 6 mos between groups. https://t.co/AuysVPFD4S https://t.co/yQ4R41hSMi
Dr. John Cush RheumNow
3 years 9 months ago
FROST study (First-line options sJIA Tx) - a prospective study to assess treatments in SJIA. 86% Rx w/ biologic (IL-1/IL-6 i) & 14% non-biologic Rx. oral GC used in 54% biologic & 90% of non-biologic. 1/2 non-biologic went onto biologics w/in 4 mos. https://t.co/8TMpEPgzOr https://t.co/N8laSs5rrZ
Dr. John Cush RheumNow
3 years 9 months ago
The Best Prescription
The craziest question that you can ask any doctor is “what is your best therapy for __?”. Crazy, because there are exponential answers, with factored layers that make each decision unique to that doctor.
https://t.co/iX8T6NSD00 https://t.co/8VUPbDjXzr
Dr. John Cush RheumNow
3 years 9 months ago
73-87% of autoimmune (RA, SLE, UCTD, APL) pts used HCQ during pregnancy. HCQ significantly reduced pre-eclampsia (20% vs 9%), early-onset pre-eclampsia (8% vs 2.5%), 2nd/3rd trimester pregnancy loss (3% vs. 0.6%) https://t.co/KrA3XtGNmK https://t.co/HwpmipgJYC
Patients taking efgartigimod, a drug being studied for use to treat chronic primary immune thrombocytopenia (ITP), exhibited a significantly greater improvement in platelet counts which are essential to clotting and stopping bleeding, compared to those taking a placebo, according to results reported from the ADVANCE IV clinical trial, which was conducted globally, including at Georgetown University Medical Center.
Clinicians could improve outcomes in their patients with rheumatoid arthritis (RA) by paying attention to certain markers of care quality, such as early referral to certified rheumatologists and prescribing standard drugs for RA, new research suggested.
The craziest question that you can ask any doctor is “what is your best therapy for __?”. Crazy, because there are exponential answers, with factored layers that make each decision unique to that doctor. Each doctor has her own cha-cha-cha algorithm to a particular problem. The problem is, we each dance to a different cha-cha-cha tune in the practice of medicine.
Dr. John Cush RheumNow
3 years 9 months ago
From a cohort of 689 SLE pts, prevalence of lupus pericarditis was 16.4% Pericarditis was signif assoc w/ renal dz (p 0.003), lymphopenia (p <.0001), thrombocytopenia (p 0.004), +APL Abs (p = 0.002) https://t.co/BndDu21aXF https://t.co/Umbq3rsF1y
Dr. John Cush RheumNow
3 years 9 months ago
207 JIA pts to rheumatology studied. Initially 61% seen by Pediatrics but only 28% referred to rheumatologist. Mean time to Dx was 56 days, but longer for polyarticular & ERA/SPA (~114 d). Faster dx w/ Younger age & fever; longer w/ sm jts https://t.co/5D8wiGxnC2 https://t.co/1n9S4JUdfF

