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Filgotinib Efficacy and Safety - 3 Years Later

MedPage Today

Filgotinib, the rheumatoid arthritis (RA) oral drug that never made it to the U.S. market but is sold across Europe, Great Britain, and Japan, remained effective for 3 years for most registration trial participants who continued in a long-term extension study, researchers said.

Swapping is Better than Cycling in Psoriatic Arthritis

A real-world cohort study suggests that psoriatic arthritis failing to respond to TNF inhibitors (TNFi) may do better if they subsequently swap to an IL-17 inhibitor, rather than cycling to another TNFi.

Treatment Options for Dupuytren’s Contracture

The NEJM reports that in a randomized, controlled, head to head trial, collagenase injections were non-inferior to limited fasciectomy in the treatment of Dupuytren’s contracture.

Blue Collar Arthritis (10.25.2024)

Dr. Jack Cush reviews the news and journal articles from this past week on RheumNow.com.

Trends in DMARD Use in Juvenile Arthritis 2001-2022

Arthritis & Rheumatology reports that treatment trends in juvenile idiopathic arthritis (JIA) in the last two decades finds rising use of newer biologic and targeted synthetic DMARDs coupled with a decline in conventional DMARD use.

Potential OA Treatment - Chemokine CCL17 Inhibition

MedPage Today

Patients with osteoarthritis (OA) of the knee receiving an investigational chemokine inhibitor showed some improvements in pain and disability, said researchers with the drug's developer.

Long-term Tofacitinib in Juvenile Idiopathic Arthritis

The long-term safety and efficacy of tofacitinib in patients with juvenile idiopathic arthritis (JIA) has been established in an ongoing long term extension (LTE) study.

SPRINGBOARD: Extended-release Intra-articular Corticosteroid Injection in Knee OA

A phase 2 trial of EP-104IAR (long-acting, fluticasone propionate) has shown 14 weeks of clinically meaningful pain relief in knee osteoarthritis (OA).

Predictors of Adverse Pregnancy Outcomes in Lupus

A large metanalysis of systemic lupus erythematosus (SLE) patients and pregnancy outcomes suggests that adverse pregnancy outcomes are more likely in those with lupus nephritis, chronic hypertension, SLE disease activity before and at concept

Anxiety and Depression Rising in Rheumatoid Arthritis

A Mayo Clinic study shows that over three decades, anxiety and depression have become more common in individuals with rheumatoid arthritis (RA).

Pain Relief in RA: JAK Better than TNF Inhibitors?

MedPage Today

Targeted drugs for rheumatoid arthritis (RA) are not created equal when it comes to pain relief, a retrospective study from Sweden indicated, although the differences appeared to be modest.

ANA+ consult (10.18.2024)

Dr. Jack Cush reviews the news and journal articles from this past week on RheumNow.com.

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