2 Canadian studies BioTrac & OBRI, w/ RA 1376 pts found 14-18%, D/C TNFI for nonresponse. Primary NR 66-87% failed to achieve LDA by DAS28-ESR, or 66-91% by CDAI. 19-61% Primary NR D/C w/in 6 mos; 61-87% of 2nd NR discontinued >12 mos https://t.co/xegAogSAQx https://t.co/IyiAStXQLs