Schulert, et al showed some beautiful work dissecting what drives monocytes and macrophages to go berzerk during Macrophage Activation Syndrome. Via transcriptional profiling, they find TRIM8 (E3 upiquitinligase) drives excessive IFNγ & is elevated in sJIA pts #EULAR2019 OP0150 https://t.co/A7ziCjcGhC