Prospective study of 4796 pts in the Osteoarthritis Initiative shows metformin use in obese pts (BMI>30) was Assoc with significantly less medial cartilage loss (0.71% vs. 1.57%/yr) & a trend towards fewer knee replacements over 6 yrs (OR 0.30, p = 0.11) https://t.co/LD0jFWtSLM