56 systemic JIA pts treated with anakinra (2.5mg/Kg/d). Pts were genotyped for 6 SNPs (from untranscribed reg IL1RN). Homozygotes >=1 SNPs associated with higher IL-1RN levels and 6 fold risk of anakinra nonresponse. #ACR20 Abst 172 https://t.co/0UU3gDfHvE