Clever from @DanielAletaha's group, asking: have trial patients really been MTX-optimised pre-enrollment? Placebo arm data from bDMARD trials x2: MTX continuation ACR20 w16: 25% v 12% (MTX works!) Should clinical trials have mandatory run-in periods? OP0127 #EULAR2021 @RheumNow https://t.co/Sx3IKOVKB6