Can we stop RA developing? Not previously. Double-blind RCT: - arthralgias+ACPA+MRI changes - but no clinical synovitis - abatacept for 6m didn't progress to arthritis: 92% v 65% improvement in MRI: 61% v 31% + benefit to 18m not shown "provocative"! #ACR21 ABST0455 @RheumNow https://t.co/TGxCBhk4r9