Downside of Holding MTX with COVID-19 Vax A recent clinical trial has shown that a 2 week hold of MTX following COVID-19 vax resulted in greater anti-SARS-CoV-2 immunogenicity; but there was an increase in flare rates after the second dose of vaccine. https://t.co/a7XfBxVkvJ https://t.co/h4VqsQYkaK