Ab1675 #ACR22 WE-CAN - Knee OA 823 randomized pts, 18 mo: Intensive Diet & Exercise (D+E) Primary endpt: WOMAC pain - 32% reduct in pain in D+E, vs 24% (PBO) 20% more likely: clinically meaningful improve Improved BMI, 6MW, HRQoL, activity Pain Rx, depression: no change @RheumNow https://t.co/Su2g4Z38FV