
MTX is a prodrug!
MTX polyglutamate is true active ingredient
1/2 of MTX PG is 60 days, compared to only 6-8 horus for MTX
Steady state is not until 27.5 weeks!
Joel Kremer at #RNL2023 @RheumNow https://t.co/hodFZ2oi11
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18-03-2023