Pegloticase Plus Methotrexate in Refractory Gout - MIRROR Study 12 mos. Results The 12-month safety and efficacy of pegloticase + methotrexate (MTX) in the MIRROR trial shows continued efficacy and tophi resolution after 12 months of therapy. https://t.co/8Jhy7gebMD https://t.co/ihZddj7b36