Abs#0608 #ACR23 @RheumNow Cenerimod: sphigosine 1-phos (S1P) 1 receptor modulator for SLE P2 CARE Study 51% of pts had high IFN1 sign., ass w/ high dsDNA Cenerimod 4 mg: decreased dsDNA and IFN-a protein at 6 mo vs b/l In high IFN pts, 4 mg Cen: decrease SLEDAI, SRI-4