PAPA (pyogenic arthritis, pyoderma gangrenosum & acne) syndrome is a hereditary autoinflammatory Dz caused by dominant mutation in PSTPIP1 (triggers IFN-γ-mediated pyrin induction & IL-18 release; can be Tx by JAK inhibition) https://t.co/fy0MnwDA5U https://t.co/l8n2EwgV0t
Links:
Interrupting an IFN-γ-dependent feedback loop in the syndrome of pyogenic arthr…
https://bit.ly/48Dz2Vc
Feb-28-2024
