Starting MTX at higher or subcut. doses yields better ACR20 responses. Review of 12 trials & 1,566 pts, shows: - higher initial MTX 25 mg (but more GI AEs) - SC MTX more ACR20 resp (85% vs PO 77%) - MTX non-response, success w/ SC MTX https://t.co/01PuDpkUIF https://t.co/vXLWEp4srH