IL-1 recept accessory protein (IL1RAP) shown to block mediators (IL-1, IL33, IL36) that may drive systemic sclerosis. In vitro, IL1RAP inhibited fibroblasts and endothelial cells; in mouse models of SSc anti-IL1RAP decr dermal & pulmonary fibrosis. https://t.co/6YE02P4rjR https://t.co/mzw7t88Jzl
Links:
Combined inhibition of IL-1, IL-33 and IL-36 signalling by targeting IL1RAP ame…
https://buff.ly/3UgOR0g
Apr-13-2024
