200 millions pts PSO 1st line, Reduction risk PsA: IL 12-23 37% & IL-23 39% vs. TNFi 2nd line ttmt, IL12-23i 32% & IL-23i 31% IL-23i 47% lower proba PsA than IL-17i 3 & 5 yrs Can't exclude some channeling bias, but that's a big signal! @RheumNow OP0010 #EULAR2024 #EULARBest