Study of at-risk & early RA Synovium suggests an early pathogenic myeloid signature (IL-1B+CCL20+ & SPP1+MT2A+ macrophage clusters) before disease onset. These display heightened CD40 expression, capable of shaping stromal cell responses https://t.co/CYmb1ro9g9 https://t.co/9pXbqHaQ2G