Genetic Link to CPPD In a first-of-its-kind genome-wide association study (GWAS) researchers have discovered two genes, RNF144B and ENPP1, that cause calcium pyrophosphate deposition (CPPD) disease in Americans of European and African descent. https://t.co/YSR6rEYzjG https://t.co/L7JyoxQp3K