Plenary session at #ACR25! #0772 When should we biopsy in SLE? In pts with uPCR 0.25-0.49 g/g + LN predictors, 69% already had LN (many Class III/V). Low C3/C4 were most important factors. 0.5 g/g cutoff may delay diagnosis and treatment. Time to rethink thresholds? @RheumNow