The next VEXAS, but also maybe we can treat it?
IDH1/2
Another clonal hematopoesis known to cause heme malignancy, but also some inflamm sequelae (autoinflamm-like e.g. PMR/GCA)
& you can directly inhibit it
Wow. We will hear more
#ACR25 LB21 @RheumNow
https://t.co/WL2ai5zb8Q https://t.co/Yi31xkhLO9
Links:
IDH1/2 Somatic Hotspot Mutations as Independent Drivers of Autoinflammation - A…
https://acrabstracts.org/abstract/idh1-2-somatic-hotspot-mutations-as-independe…
29-10-2025
