Depression and Anxiety Associated with Inability to Achieve Remission in RA and PsA Save
Dr. Aurelie Najm reports on abstract POS0946 presented at Eular 2024 in Vienna, Austria.
Transcription
Hi everyone, this is Aurelie Najm. I am reporting for RheumNow live from Vienna Conference Center. It's day three and there's been so much great science so far. I want to draw your attention on one poster that I saw this morning that reminded me that maybe I need to do a bit more for my patients in my current practice when it comes to mental health. This is a poster, poster nine forty six, that looked across diseases in both rheumatoid arthritis and psoriatic arthritis.
There were two cohorts, four hundred plus patients with RA from the T RIGS cohort, five hundred plus patients with PSA from the DPR cohort, and what they looked into was whether or not people had anxiety, depressive symptoms, and so on. And so, looked at baseline, and then they looked how that would affect the outcome at two years. And so, first of all, big numbers. At baseline, one patient out of five had depressive symptoms. One patient out of three had anxiety disorder.
I mean, we want to compare that with the general population, and it didn't do that, but, you know, it still looks like it's a lot. That was for RA, and then in PSA, was roughly twenty percent. So, one patient out of five for each depression and anxiety, which again is a lot. And so one thing that was really interesting as well is that those people that do display depressive symptoms and anxiety disorder were less likely to achieve remission in two years, whether they've got RA or PSI, and the odd ratio are pretty impressive, especially in PSA. The odd ratio to not achieve remission at two years when you've got depression is like six.
So it really does matter. I mean, obviously there's a lot of confounding factor there potentially, but also does it really matter whether or not people have confounding factors? Maybe this is just something we need to address and treat appropriately, which I don't think a lot of us do on a regular basis. Now the other thing that I found really interesting, they look at one year and those people that displayed depressive symptoms at baseline also had higher ESR at one year and these are RA patients and those PSA patients with depression at baseline had a higher number of swollen joint count as well as CRP, which as well is not only how do they feel, but they do display higher signs of inflammation as well. So once again, this could be related to confounding factors and we need to not exclude that, But I think this is definitely something that we need to look into more.
Follow me on Twitter for more content, or reallyromo, and follow RheumNow, and don't miss our 6PM panel for a recap of the day. See you around.
There were two cohorts, four hundred plus patients with RA from the T RIGS cohort, five hundred plus patients with PSA from the DPR cohort, and what they looked into was whether or not people had anxiety, depressive symptoms, and so on. And so, looked at baseline, and then they looked how that would affect the outcome at two years. And so, first of all, big numbers. At baseline, one patient out of five had depressive symptoms. One patient out of three had anxiety disorder.
I mean, we want to compare that with the general population, and it didn't do that, but, you know, it still looks like it's a lot. That was for RA, and then in PSA, was roughly twenty percent. So, one patient out of five for each depression and anxiety, which again is a lot. And so one thing that was really interesting as well is that those people that do display depressive symptoms and anxiety disorder were less likely to achieve remission in two years, whether they've got RA or PSI, and the odd ratio are pretty impressive, especially in PSA. The odd ratio to not achieve remission at two years when you've got depression is like six.
So it really does matter. I mean, obviously there's a lot of confounding factor there potentially, but also does it really matter whether or not people have confounding factors? Maybe this is just something we need to address and treat appropriately, which I don't think a lot of us do on a regular basis. Now the other thing that I found really interesting, they look at one year and those people that displayed depressive symptoms at baseline also had higher ESR at one year and these are RA patients and those PSA patients with depression at baseline had a higher number of swollen joint count as well as CRP, which as well is not only how do they feel, but they do display higher signs of inflammation as well. So once again, this could be related to confounding factors and we need to not exclude that, But I think this is definitely something that we need to look into more.
Follow me on Twitter for more content, or reallyromo, and follow RheumNow, and don't miss our 6PM panel for a recap of the day. See you around.
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