Tweets
IL-6i in Behcets? Lit Review finds 25 articles papers, 74 pts (31 TNFi naive, 45 TNFi prior Rx). Pts Rx w/ tocilizumab IV. TCZ given for vascular, CNS , ocular & mucocutaneous. TCZ was effective in 87% TNF naive & 80% in TNFi Experienced pts. https://t.co/u1jnR9gb1L https://t.co/Rkqch4MVWi
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Dr. John Cush @RheumNow ( View Tweet )
3 years 9 months ago
Is there link between PsA & autoinflammatory Dz? Study of 120 #PsA pts found 31% w/ AID gene variants (AP1S3, PLCG2, NOD2, NLRP12, all monoallelic variants adn 1/2 genes assoc w/ autosomal dominant disorders. https://t.co/1cVFErPV6o https://t.co/QtRHrZJLJI
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Dr. John Cush @RheumNow ( View Tweet )
3 years 9 months ago
Hydroxychloroquine Dosing and SLE Flares
JAMA cohort study examining HCQ dosing in patients with SLE suggests that HCQ doses of 5 mg/kg per day or less, was associated with a higher risk of lupus flares, including moderate or severe lupus flares.
https://t.co/1krevZo64c https://t.co/XEybtcFvNR
Links:
Dr. John Cush @RheumNow ( View Tweet )
3 years 9 months ago
STAR-RA study - real world claims data shows tofacitinib doesnt increase malignancy risk. Study of 83,295 pts (10,504 TOFA). Risk of malignancy w/ TOFA not increased (HR 1.01) w/ RWE or RCT-duplicate cohort (HR 1.1; 95% CI 0.85, 1.62) https://t.co/9YWmXBTkWf
Links:
Dr. John Cush @RheumNow ( View Tweet )
3 years 9 months ago
RINOMAX Trial studied single dose of 500 mg rituximab IV in myasthenia gravis - 47 MG pts randomized to RTX or PBO, after 4 mos RTX response (71% vs 29%) superior to PBO. Further studies are needed https://t.co/ffko7uMpk7
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Dr. John Cush @RheumNow ( View Tweet )
3 years 9 months ago
Colchicine vs cimetidine in PFAPA (Periodic fever, aphthous stomatitis, pharyngitis, adenitis) syndrome. 72 pts given COL vs CIM x 3 mos: # of febrile attacks was significantly decreased by both Rx (noninferior to each other) https://t.co/HkmzwGNwFC
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Dr. John Cush @RheumNow ( View Tweet )
3 years 9 months ago
Heavy Metal Rheumatology 🤘
https://t.co/4fkwOsH2yf https://t.co/otQP9a6h6S
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Dr. John Cush @RheumNow ( View Tweet )
3 years 9 months ago
USPSTF Recommends Screening for Anxiety and Depression
The U.S. Preventive Services Task Force has recommended that general practitioners actively screen and identify anxiety and depression in all adult patients under 65 yrs.
https://t.co/8qOHzV52d8 https://t.co/tOzZQDHR1M
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Dr. John Cush @RheumNow ( View Tweet )
3 years 9 months ago
Worldwide, IL-6 inhibitors are approved for RA, poly JIA, systemic JIA, AOSD, GCA, Takayasu arteritis, Castleman’s dz, CAR-T-cell-induced cytokine release syndrome, neuromyelitis optica spectrum disorder and severe COVID-19 https://t.co/SRPjerXnGS
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Dr. John Cush @RheumNow ( View Tweet )
3 years 9 months ago
Patients with incident gout have a 44% increased risk of 1st-time ACS, higher in women than in men. This risk is largely explained by the underlying comorbidities, Swedish study of 20,146 pts w/ incident gout. Risk decr in multivariate analysis (15-20%) https://t.co/KbjszXNFSQ
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Dr. John Cush @RheumNow ( View Tweet )
3 years 9 months ago
Italian study of Apremilast in 356 #PsA (age 60yrs) pts Followed ~17 mos, shows retention rate @ 12, 24 & 36 mos to be 85.6%, 73.6%, & 61.8%. D/C primarily for inefficacy (18-34%), GI Sx (24%). Best persistence w/ oligoarthritis https://t.co/iIy86cUHB5
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Dr. John Cush @RheumNow ( View Tweet )
3 years 9 months ago
Open label, multicenter study of 70 Psoriasis pts treated w/ apremilast shows no change in aortic vascular inflammation (FDG-PET) at wks 16 & 52, but did decr. several cardiometabolic biomarkers (IL1b, ferritin) & 5-6% loss of SC fat https://t.co/iJOgZ5kHLb
Links:
Dr. John Cush @RheumNow ( View Tweet )
3 years 9 months ago
