Tweets
Record Use of Marijuana and Hallucinogens in Young Adults
The NY Times reports that a recent survey of drug use indicates that daily consumption of marijuana among young adults nearly doubled in the last decade.
https://t.co/Dvj4nUNdtg https://t.co/BRkq8nb5sz
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Dr. John Cush @RheumNow ( View Tweet )
3 years 10 months ago
Phase 2 RCTs are evaluating TLR 7 & TLR 8 blockade in SLE - BMS has afimetoran and Merck has enpatoran (both blocking TLR7/8) https://t.co/3TavS7NE99 https://t.co/lZyp1QLNqP
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Dr. John Cush @RheumNow ( View Tweet )
3 years 10 months ago
Myths & Misconceptions with Febrile Disorders
Still’s disease and autoinflammatory disorders are rare conditions unified by recurrent fevers and inflammation of skin, joints, and other organs.
https://t.co/vdZWR1cwDx https://t.co/OoGIBjpZGn
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Dr. John Cush @RheumNow ( View Tweet )
3 years 10 months ago
Top 60 brand-name drugs in US cost ~395%higher than other high-income countries. New legislation by Congress lets Medicare negotiate drug prices & cap out-of-pocket costs @$2,000/yr. Read more on proposed restrictions importing drugs from Canada https://t.co/z507qRNj4E https://t.co/kXnqIQkIp7
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Dr. John Cush @RheumNow ( View Tweet )
3 years 10 months ago
Study of 9611 pts w/ hip or knee arthroplasty for #OA tested aspirin (100 mg/d) vs enoxaparin (40 mg/d) (x35d w/THA; 14d after TKA). Enrollment prematurely halted as VTE rate was 3.45% w/ ASA and 1.8% w/ enoxaparin (superior to ASA: P= .007) https://t.co/jvuely8L56 https://t.co/O1TxCjaSPU
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Dr. John Cush @RheumNow ( View Tweet )
3 years 10 months ago
VTE (clots) w/ JAK inhibitors? Metanalysis of JAKi in 9711 Atopic dermatitits pts shows no significant assoc between JAK and incident VTE (HR 0.95; CI 0.62-1.45; or 0.23 VTE/100PYs). Actual #s: 3 VTE per 5722 pts (0.05%) https://t.co/VesXp5WSpY https://t.co/JsFSKzmbjN
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Dr. John Cush @RheumNow ( View Tweet )
3 years 10 months ago
Eval of 161 acute mono/oligoarthritis pts (gout, CPPD, controls) shows US of 2 joints (target jt, knee, MTP1, wrist) showed Dx accuracy (>90%), high specificity for gout (0.92-0.96) & CPPD (0.90-0.97); w/ sensitivity ranged from 0.73 to 0.85 for gout https://t.co/hW3pmz86kH https://t.co/IFVpINgybY
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Dr. John Cush @RheumNow ( View Tweet )
3 years 10 months ago
NICE has approved upadacitinib (Rinvoq) for availability in England & Wales for use in adults w/ active ankylosing spondylitis not controlled with conventional therapy, only after TNF inhibitors are tried or not suitable https://t.co/MV47NPb2EF https://t.co/9Le2Sj5aNI
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Dr. John Cush @RheumNow ( View Tweet )
3 years 10 months ago
JAMA Patient Handout on common causes of patient hair loss
1. Patterned: androgenetic alopecia
2. Diffuse: telogen effluvium
3. Focal: alopecia areata
https://t.co/caL41RdxaV https://t.co/WsStH3drMk
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Dr. John Cush @RheumNow ( View Tweet )
3 years 10 months ago
Bidirectional Association Between Depression and Rheumatoid Arthritis
A recent meta-analysis suggests a bidirectional association between RA and depression. Finding RA patients with depression yields an 80% increased mortality risk.
https://t.co/1o2ObHd76V
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Dr. John Cush @RheumNow ( View Tweet )
3 years 10 months ago
Voltage-gated Na channels (NaV) in nociceptive neurons may lead to pain stimuli in #OA. Tamoxifen metabolites inhibit NaVs & was studied in animal model of OA, showing analgesic effects equal to CBD and lidocaine. https://t.co/1Tu9No8ZnT https://t.co/JKoxiAh15O
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Dr. John Cush @RheumNow ( View Tweet )
3 years 10 months ago
Weight Loss Slows Knee OA Progression
Declines in body mass index (BMI) were linked with slower worsening of knee osteoarthritis (OA), according to data from three large longitudinal cohort studies.
https://t.co/dxvqueq7B5 https://t.co/Odx73kOeaO
Links:
Dr. John Cush @RheumNow ( View Tweet )
3 years 10 months ago
