Transcription factor ETS-related gene (ERG) is an orchestrator of lung capillary homeostasis & repair. Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis https://t.co/TMFBa74ob7 https://t.co/n60DwGaa74

Heterozygous deficiency of Aggrecan (proteoglycan w/in cartilage) gene: manifests as inherited short stature, early-onset osteoarthritis, degenerative disc disease, osteochondritis dissecans, increasing joint pathology over time https://t.co/4iQdNL79oB https://t.co/qxStgE641v https://t.co/EHPJuIeQGt

Treatment Options for Still's Disease Gotta know if you're treating “systemic” or “articular” (arthritis) Still’s disease. Most Still’s patients have a dominance of one or the other. With certainty, the right therapy for the right symptoms can be chosen. https://t.co/fPBk6PdCaD https://t.co/u3RfWsnyv6

Review of Clinical Trial measures in systemic sclerosis: -RCTs focus on skin dz, ILD or Pulm HTN using mod. Rodnan skin (MRSS), 6-min walk -FVC is surrogate measure for SSc-ILD - Composites: CRISS, the EUSTAR-AI -Future: Skin mRNA biomarkersTHBS1 and COMP https://t.co/2KD892VIUy https://t.co/9giddEl9I4

11.5% of Crohns pts have TNFi use contraindications (either MS, CHF, neoplasia, infx risk, TNFi AE, comorbidities, SLE. Alternatively GI survey respondents use ustekinumab (76%), vedolizumab (249%), or tofacitinib (0.5%) https://t.co/6ApUz93iS0 https://t.co/PTmnsTd2Wh

Novel autoinflammatory disease with an ALPK1 gain-of-function mutation: ▶️ R etinal dystrophy ▶️ O ptic nerve oedema ▶️ S plenomegaly ▶️ A nhidrosis ▶️ H eadache https://t.co/9GbjZLMFCo https://t.co/Bh0MkYmrDA

🌏 Today is World Sjögren's Day!🌍 🩺 Sjögren's is not Just Dry eyes👁️ and Dry Mouth👅👄 - there's much more to it There's still a lot about this 'invisible' #Autoimmune Disorder, we don't know Clinical Features and Pathogenesis #LetstalkaboutSjögrens #MedTwitter #RheumTwitter https://t.co/t9toed8MG7

Anyone who thinks BA.5 is just another variant isn't paying attention >200,000 new cases yesterday. Vertical. https://t.co/x7wziHMZ9K

213 #SLE pts were screened for Cryoglobulinemia (2013 -2017); CG is frequent in SLE (66%), but mostly asymptomatic. Mean levels 40mg/L (0-228). Cryo Vasculitis in 15% w/ purpura, ulcers, digit ischemia, arthritis, GN (5%) or CNS (19%) https://t.co/jRVXCj4MlV https://t.co/gamOOwkJ5R

Overdose deaths increased to 107 000 deaths in US in 2021, with significant racial disparity. Higher overdose rates seen in American Indian, Alaska Natives and Blacks. WORSE during COVID - 2020, overdose rates were 7 times higher in Blacks than Whites https://t.co/PMRo9gbzZl https://t.co/CgxgemyEA7

JAMA patient (resource) handout on Lumbar Spinal Stenosis! https://t.co/fl5K5Ve6fY https://t.co/aLHs6sKE1o