New podcast ready for download! Fever Pitch--Dr. Jack Cush reviews the new studies and drug approvals and new insights into febrile disorders from the past week. https://t.co/GdntsVNyfS https://t.co/3QdJHNlIKQ

Should Physical exercise be recommended in dermatomyositis and polymyositis: a systematic review of 19 studies and 298 patients showed significant improvements in strength & aerobic capacity without change in CK levels or exacerbations https://t.co/G09ITAku2U https://t.co/6Mj0UAgkDE

MRP8/14 as a Biomarker in Systemic Juvenile Idiopathic Arthritis A large cohort study of children with febrile disorders has demonstrated the diagnostic utility of MRP8/14 in diagnosing systemic JIA patients (SJIA) in clinical practice. https://t.co/Gma3h9Iuqn https://t.co/7GOeES4bbA

RTX Induction and Maintenance in Older ANCA–Associated Vasculitis Patients A cohort study suggests that RTX use among patients 75 years and older with ANCA–associated vasculitis (AAV) is efficacious but also has a high risk of serious adverse events. https://t.co/HF9hyQcHZV https://t.co/xpDSohFcRK

Viscosupplementation Ineffective in kOA The BMJ has published the results of a metanalysis showing strong conclusive evidence that viscosupplementation in kOA has minimal effects on pain/reveals strong of an increased risk of adverse events. https://t.co/hOy0JczC4I https://t.co/Hc2rwbZS3q

Immunoprofiling of synovial CD4+ T cell subsets shows that ACPA+ pts differ from ACPA- RA by having high expression of adhesion G-protein coupled receptor 56 (GPR56) on synovial CXCL13high TPH CD4+ T cells expressing LAG-3 https://t.co/LQ77CIdh9o https://t.co/chfmLfIqeF

Ustekinumab (IL-12/23i) phase 2 study was successful in #SLE; but the phase 3 LOTUS study of 512 pts, UST was NOT superior to PBO (SRI-4 44% v 56%) at 1 year. Study was halted for lack of efficacy (but no safety concerns). https://t.co/X5CKYVFxg5 https://t.co/6HVw6AMJPL

QD Clinic - Stills (or Not) with Hives What do you think? 40 yr. woman with fevers, hives, and LFTs. https://t.co/IZNnWzerOL https://t.co/sUGPuy2tKC

mitochondrial DNA can drive SLE by PMN uptake, NETs, activation of STING & type-I IFN. Maybe same for Autoinflammatory responses were oxidized mtDNA provokes cGAS-STING, binding cytosolic NLRP3, triggering inflammasome activity. https://t.co/sTDTkoMQX2 https://t.co/wXhVzzIFRC

Steroid Injection for Chronic Achilles Tendinopathy Adding a corticosteroid shot to exercise therapy significantly improved symptoms of chronic Achilles tendinopathy, a 100-person randomized trial found. https://t.co/sdYmsVpBsU https://t.co/r9zFVUmE88

Watch: What's new in sarcoidosis? https://t.co/GnU1FDnUhn https://t.co/H1omKPtQmn

NEJM Case - 17-Year-Old Girl with Fever and Cough and B/L lower lobe infiltrates. 3 wk hx started w/ conjunctivitis, SOB, Cough fever myalgia & knee pain. No rash. T 38.5°C, W 11.5, H/H 6.9/21, P526k, CRP 77mg/L, UA 2+ protein, neg COVID tests. https://t.co/VOiW7DIdBR https://t.co/1GWA2gAgeK