Combined Nordic registry data on demyelination and inflammatory neuropathy with TNFi. Demyelination 2-3 times higher in SpA vs RA. No difference between ETN and monoclonals. @RheumNow #EULAR2022 OP0060 https://t.co/SK9s7aVaZk https://t.co/hZ5VaoTe4X

#POS0190 #EULAR2022 Disappointing news. Despite +ve Phase 2 RCT, Results from Phase 3 RCTs of Baricitinib in #lupus is inconclusive 💠SRI4 was met in BRAVE1 but not BRAVE2 despite identical study 💠BILAG MSK & Skin improved in BRAVE1 only BICLA wasn’t reported @RheumNow https://t.co/IfJRYEwFY8

Combined nordic registers study: 🧠 demyelinating and inflammatory neuropathies in 50000+ patients starting TNFi 📍DML SpA > RA 📍INP SpA = RA 📍ETA = Other anti TNFi But no csDMARDs control group OP0060 #EULAR2022 @RheumNow https://t.co/LYqUW22rMg

#Bestinclass #EULAR2022 #PsA @RheumNow #OP0027 #CVE #MACE with #Tofacitinib in #psoriatic #arthritis and #PsO with median 3 to 4 yrs Rx. 40% metabolic syndrome which is high. There was no comparison. As expected hose with ⬆️MACE risks had more outcomes. https://t.co/sTjFHsUxzi

The amazing @SuAnnYeoh1 oral presentation showing terminally differentiated T effector memory re-expressing CD45RA are associated persistent disease activity in TNF non-responders (but not other bDMARDs) ?role in driving disease @RheumNow #EULAR2022 OP0011 https://t.co/OFradjuGvo https://t.co/flpFmcvixO

Dr Fabian Proft @ProftDr present CONSUL open label RCT of effect of adding NSAIDS to TNFi on structural outcomes. Bottom line, no significant difference in mSASSS. However new syndesmophytes in 11% vs 25%. @RheumNow #EULAR2022 OP0018 https://t.co/OcYH6oKbJQ https://t.co/kxH5vUdibe

178,000 cells from knee synovium studied to eval diff in RA vs PsA transcriptomes. With RA: 👉synov Tcells ⬆️TGFB1 express'n 👉⬆️FAP+ THY1+ synovial fibroblasts 👉receptor ligand network➡️synovial T cell & macrophage synergy 👉IL-1b & TGFb synergy #EULAR2022 OP0067 @rheumnow https://t.co/0uaFyqZqBg

#Plenary OP0066. Consider Whipple Dz in pts inflammatory rheum dz Screen with PCR saliva/stool samples, confirm with duodenal bx or PCR on joint fluid. pts on doxycycline and HCQ can lead to rapid remission. @rheumnow https://t.co/VcGp8pr3dT

NORD-STAR substudy looking at anticoagulant effects. Important as RA assoc. ⬆️DVT/PE. DMARDs improve haemostatic imbalance, with bDMARDs stronger effect than csDMARD (may relate to better disease control with this) @RheumNow #EULAR2022 OP0059 https://t.co/TKwAZMOZjY https://t.co/IazrfD7z7k

#POS0186 #EULAR2022 AURORA2 (Extension of original RCT to 2 years) showed: 💠#lupus nephritis patients on voclosporin maintained meaningful low uPCR and stability of eGFR at 2yrs 💠No unexpected safety signals @RheumNow https://t.co/lnohgW7BsK