TLR7 signaling impt to SLE as it drives type I IFN & activation of autoreactive B cells. Nature reports missense TLR7 (Y264H) variant from severe lupus induces guanosine & cGMP & causes murine lupus when introduced into mice. https://t.co/VZioZfcJQ6 https://t.co/AtxWD4XGBF

Phase 2b DBRPCT of Intranodular injections of adalimumab in 140 pts w/ Dupuytrens contracture showed signif reduction nodule size and hardness ((−4·6 vs −2·2; p=0·0002) at 12 months https://t.co/9wBOeQNUdL https://t.co/HOR8rzYuRa

Dr. Judith James on environmental factors that contribute to lupus risk and expression. #UTSWSLE2022 https://t.co/MGE51vlDMY

RBCs from SLE patients retain mitochondrial proteins that may either lead to type I IFN or be taken up by myeloid cells. (V. Pascual) #UTSWSLE2022 https://t.co/VdQGRDUMvX

Dr. Pascual shows that signatures show IFN or plasmablast or PMN/Myeloid signatures, thus identifying 7 subsets of lupus kids #UTSWSLE2022 https://t.co/3BAxPdAKw8

Clinical evidence of type I IFNa excess expressed in clinical SLE (Dr. Virginia Pascual) #UTSWSLE2022 https://t.co/To2U9ZtxU3

Professor Chandra Mohan on pathogenesis and immunogenetics of #SLE - over 180 genes linked to the pathogenesis, modified by infection (bigger role for EBV?) hormones, smoking, hormonal status. #UTSWSLE2022 https://t.co/aKNpxZfdc6

Efficacy of Subsequent b/tsDMARD Use in Rheumatoid Arthritis https://t.co/5dXe0AdNzE https://t.co/eS4KdaKBmC

Three (3) Worst Drugs to use in #Lupus patients who want to be pregnant (MTX, MMF, CTX) #UTSWSLE2022 https://t.co/YBeLTuRLO1