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Czech registry compared drug survival csDMARDs vs TNFi monotherapy. Drug retention higher w/ combo (47 vs 23 mos; p < 0.001) than TNFi monotherapy. 5 yr survival was better 45% vs 26%; Combo w/ MTX > other csDMARDs (p = 0.003). https://t.co/pjbXwEQ53K https://t.co/nZj64Wk3Pt
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Dr. John Cush @RheumNow ( View Tweet )
4 years 3 months ago
520 RA pts were screened with FibroScan (liver fibrosis)- F3 or F4 liver fibrosis seen 13.3% of controls vs 12.7% arthritis pts. MTX was not significantly correlated w/ higher FS scores. Liver stiffness was correlated w/ BMI, waist, male , age. https://t.co/iKvsITCs33 https://t.co/Dqos1MT431
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Dr. John Cush @RheumNow ( View Tweet )
4 years 3 months ago
Steroids associated with adverse events during pregnancy @UmaMahadevanIBD @MayoClinicGIHep https://t.co/VR5CZUH1S7
Edward Loftus @EdwardLoftus2 ( View Tweet )
4 years 3 months ago
Avacopan efficacy in renal failure in AAV. Appears to have benefit in renal disease that is more marked the more severe the disease is #Vasculitis22 https://t.co/3zsxjTLj62
Richard Conway @RichardPAConway ( View Tweet )
4 years 3 months ago
The striking and most welcome streak of US Covid hospitalizations going down every single day since mid-January continues, now well below the prior pandemic nadir, and even after facing BA.2 variant dominance in parts of the country weeks ago 👍 https://t.co/WUZUCb2TOK
Eric Topol @EricTopol ( View Tweet )
4 years 3 months ago
#ClinicalPearl Overall #azathioprine wins for maintenance of remission in ANCA associated #vasculitis with equal remission in MPO+ but less with AZA inPR3+. So use AZA but if not tolerated sometimes MMF is ok. Otherwise consider #Leflunomide or if bad organ involvement #Rituximab https://t.co/efi8cKQ36B
Janet Pope @Janetbirdope ( View Tweet )
4 years 3 months ago
ALEVIATE - small study of Alemtuzumab (anti-CD52) in 23 refractory ANCA-Assoc vasculitis or Behcets— 16/23 (70%) had either complete (6/23, 26%) or partial (10/23, 44%) response at 6 months. 10 SAE in 7 (30%) pts https://t.co/EciG0Mkn4i https://t.co/7UmDA4NxqV
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Dr. John Cush @RheumNow ( View Tweet )
4 years 3 months ago
RheumNow's PsA Campaign with enhanced coverage of Psoriatic Disease is sponsored by Janssen. All content is chosen by RheumNow + its faculty. #PsAlways https://t.co/is2O1dewcr
Dr. John Cush @RheumNow ( View Tweet )
4 years 3 months ago
Network metaanalysis studied 46 RCTs biologics in #PsA. Some TNFi's numerically (not signif) better vsn interleukin inhib for ACR resps, but worse on PASI resps (IL-23, IL-17i had better PASI responses); No diff in enthesitis & dactylitis resps https://t.co/AvnoLRVi6C #PsAlways https://t.co/BSl9hVbIx6
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Dr. John Cush @RheumNow ( View Tweet )
4 years 3 months ago
Metanlysis of psychological interventions for chronic low back pain (97 RCTs, 13,136 pts) finds that Only behavioural therapy delivered w/ physiotherapy care (mainly structured exercise) reduced pain intensity up (high quality evidence) https://t.co/wHHvj0vey9 https://t.co/PBwyitTZxK
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Dr. John Cush @RheumNow ( View Tweet )
4 years 3 months ago
211 pts presenting w/ hot swollen joint to the ER; 28 w/ septic arthritis; pseudogout 32; gout 50; & others: 101. Predictors of Septic Arthritis: RA (OR 3.4); skin infx (OR 3.3); liver Dz (OR 9.9); knee involv (OR 3.5); immunosuppressive use (OR 3.5) https://t.co/uASovNVOWb https://t.co/Fq3obVDavm
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Dr. John Cush @RheumNow ( View Tweet )
4 years 3 months ago
TONIGHT! Join us for Tuesday Night Rheumatology on April 5 at 7pm ET. Register today! https://t.co/jewQ9RE88n https://t.co/EfFiztByub
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Dr. John Cush @RheumNow ( View Tweet )
4 years 3 months ago


