Tweets
Best of 2021: Avacopan - Is it Really a Win for ANCA-Associated Vasculitis?
The NEJM has reported the results of a study showing that avacopan, a C5a receptor inhibitor, is as effective as steroids at treating patients with ANCA-AAV.
https://t.co/cm9PX66zE7 https://t.co/e7S5C6eugK
Links:
Dr. John Cush @RheumNow ( View Tweet )
4 years 7 months ago
Best of 2021: Very high levels of IL-18 IL-18 (> 10 000 pg/ml) is associated with Macrophage Activation syndrome (with systemic JIA) as well as primary and secondary Hemophagocytic lymphohistiocytosis (HLH) https://t.co/FQPAHZTi4M https://t.co/UkNh2no123
Links:
Dr. John Cush @RheumNow ( View Tweet )
4 years 7 months ago
Danish Cohort study of 5310 cutaneous LE or SLE pts between 1995-2014 (7-8 yrs F/U and 40.724 PYs) shows an overall increased cancer risk for CLE (SIR 1.35)and SLE (1.45), esp a 3-4 fold increased risk for NHL, hematological, pancreatic and lung cancers https://t.co/MFPLG9ifGU
Links:
Dr. John Cush @RheumNow ( View Tweet )
4 years 7 months ago
One-Third Rheumatoid Risk from Lifestyle
Analysis of the NHANES data suggests that 1/3 of the risk of developing RA in the USA is attributable smoking, obesity and alcohol intake.
https://t.co/SAVzBGlAoP https://t.co/bIhmCkufmC
Dr. John Cush @RheumNow ( View Tweet )
4 years 7 months ago
Best of 2021: Israel provides COVID vaccine answers for rheumatic disease patients
https://t.co/3mWEjdAnLL https://t.co/It5VjbQMoI
Links:
Dr. John Cush @RheumNow ( View Tweet )
4 years 7 months ago
Rheumatologist survey - How do you aspirate (or injx) a knee effusion - what is your needle approach?
Dr. John Cush @RheumNow ( View Tweet )
4 years 7 months ago
Best of 2021: Seronegativity in RA studied using sera and microarrays from 559 RA (283 ACPA-) found 9 autoAbs w/ >90% specificity for seroneg RA. anti-PTX3 & anti-DUSP11 had best performance w/ sensitivity 38% & specificity 88% https://t.co/jFAnpQzmve
Links:
Dr. John Cush @RheumNow ( View Tweet )
4 years 7 months ago
Best of 2021: Cutaneous manifestations of ANCA-assoc vasculitis studied in 1184 GPA, MPA, EGPA pts and found to assoc w/ more severe disease. Common were petechiae/purpura (15%); allergic Sxs such as pruritus, urticaria, were more common in EGPA
Dr. John Cush @RheumNow ( View Tweet )
4 years 7 months ago
Best of 2021: Petri et al shows higher HCQ levels associated with reduced thrombosis risk, study of 739 SLE pts - 38 patients (5.1%) had thrombosis. HCQ level lower in thrombosis pts (720 vs 935, p=0.025). 69% decr in VTE when levels >1068 ng/mL vs <648 ng/mL
Dr. John Cush @RheumNow ( View Tweet )
4 years 7 months ago
Best of 2021: Colchicine suppresses MSU & CA pyrophosphate crystal activation of Nod-Like Receptor Protein 3 (NLRP3) inflammasome, thereby suppressing caspase-1 activation and the subsequent release of IL-1β and IL-18. Great review by Pillinger et al
Dr. John Cush @RheumNow ( View Tweet )
4 years 7 months ago
Best of 2021: Metanalysis of Rituximab use in EGPA (Churg-Strauss) found 19 cohort studies, 8 case series, 18 cases, for a total of 368 EGPA patients. RTX yielded 80% w/ complete or partial remission (w/ more complete responses in pANCA+ pts) https://t.co/cIu6V6Cg8W https://t.co/Pw0ZpqqcB7
Links:
Dr. John Cush @RheumNow ( View Tweet )
4 years 7 months ago
Best of 2021: Plasmapheresis Indications : TTP, HUS, Cryoglobulinemia, Hyperviscosity, Myasthenia gravis, Goodpastures, Catastrophic APL Syn, Chr inflamm demyelinating polyneuropathy, Removal of drugs/toxins, Alveolar hemorrhage, ANCA vasculitis (questionable)
Dr. John Cush @RheumNow ( View Tweet )
4 years 7 months ago
