Interesting study on Pioglitazone significantly improving vascular stiffness and cardiometabolic parameters vs. PBO in #lupus by @sarfarazhasni et al. Pioglitazone: potential tx option to reduce CV risk in SLE?🧐 @RheumNow #ACR21 abs1748 https://t.co/ow3zA2hhnx

ePROs for SpA patients showed a trend in reduction of disease activity, improved clinic workload, individualized treatment with good patient/physician user satisfaction Abs#1788 #ACR21 @RheumNow https://t.co/04kUikdIZu https://t.co/uO9junUqKi

Sleep disturbance common and associated with disease activity (both PRO and physician-assessed) in RA. Need further studies to evaluate causal directions, but may well be bidirectional? Abstr#1666 #ACR21 @RheumNow https://t.co/eK65I92wPg

#ACR21 Ab#1683: ABA for RA-ILD ⭐️Stabilization of DLCO, FVC, HRCT in UIP and NSIP in 106 UIP, 84 NSIP patients ⭐️Stabilization or improvement of dyspnea in 91% UIP, 95% NSIP pts @Rheumnow https://t.co/qfgDmooGOj https://t.co/gz6Jk15nUs

☄️Late breakingTRAIL1 RCT Pirfenidone on RA-ILD. ✨Primary outcome on incidence of decline of >10% FVC or death not met 11% PIR vs. 15% PBO OR=0.67 p=0.48 BUT ✨underpowered ✨reduces decline in FVC(ml) over 52wk (-66 vs. -146, p=0.0082) ✨safety ok #ACR21 #AbstL10 @RheumNow https://t.co/IxYDE3lN1s

Safety update for #filgotinib in #RA over ~2.2yrs treatment 👉🏼Well-tolerated with no ne safety concerns since 2020 👉🏼AE incidence rates decreased or remained stable 👉🏼Slight incr rates of NMSC & non-NMSC malignancies Abs#1698 #ACR21 @RheumNow https://t.co/0jbZFVgiyN https://t.co/yOlntLwQlU

#ACR21 Ab#1655. Respiratory Ifn in RA on bDMARD ▶️1 group was initiated into vaccination program vs usual care ⭐️Vaccinated group had ⬇️ admissions from respiratory ifns. 44% ⬇️ severe resp ifn 💉programs work! @Rheumnow https://t.co/pljR6DbAtU https://t.co/goSHGID8qG

Isolated axial involvement exists in 2-5% of PsA patients. In 576 patients 495 (31.4%) had axial disease, of which 32 (2.0%) had isolated axial disease. HLA-B*27+ and lower HAQ scores were associated with isolated axial disease @RheumNow #ACR21 Abst#1775 https://t.co/Y1EAJlA0mT https://t.co/8oZhN3mT30

In this study: 💊No correlation bet QTc interval & whole blood HCQ level regardless of dose, CKD or abnormal TTEs in #lupus pts 💊+correlation bet QTci & HCQ levels in pts w/ QTc prolonging drugs but not >456ms Reassuring, dispels concern on HCQ use @RheumNow #ACR21 abs1743 https://t.co/kpASRAXJB1

#Multimorbidity in women with #rheumatoidarthritis is increased compared to men with RA. However, women and men without RA have similar levels of multimorbidity. Abs#1656 #ACR21 @RheumNow https://t.co/iXhXOldTy0 https://t.co/CsOM7odE69