Tweets
#ACR21 Great Debate Dr. Brad Rovin:
Voclosporin: Combo with MMF is effective pts of diverse racial and ethnic backgrounds.
⭐️Big plus for a disease with large healthcare disparity issues
@Rheumnow https://t.co/rMpCRPLLGQ
Eric Dein @ericdeinmd ( View Tweet )
4 years 9 months ago
Abst0385 #ACR21 @RheumNow Serum IL-22 significantly ⬆️ in pts w/ AxSpA (29 pts) vs alternative Dx &healthy (p< 0.001) suggesting serum IL-22 as diagnostic/differential biomarker for AxSpA. levels did not correlate w/mSASSS, BASDAI, ASDAS indices or serum CRP- no prognostic value https://t.co/2B8EWMaSDn
Olga Petryna @DrPetryna ( View Tweet )
4 years 9 months ago
A cohort study on #uveitis in SpA by @DrDDRheum et al. showed that the axSpA grp had ⬆ incidence of uveitis and ⬆ uveitis flare rates vs. PsA grp.
Predictors of ⬆ risk of new uveitis flare accdg to grp👇
🔸PsA: Male and HLA-B27+
🔸axSpA: ⬆ ESR and CRP
@RheumNow #ACR21 abs0064 https://t.co/8IIET1zcYH
sheila @RHEUMarampa ( View Tweet )
4 years 9 months ago
RELIANCE observational interim analysis in PFS pts treated w/ CAN. 168 CAPS, TRAPS, HIDS/MKD and FMF pts enrolled starting 10/17 - 12/20. 101 pts experienced an AE, 9 drug-related SAE. See table below. Abs 1090 #ACR21 #RheumNow @RheumNow https://t.co/4ship1G1tY https://t.co/EFlgUGNXdD
Dr. Rachel Tate @uptoTate ( View Tweet )
4 years 9 months ago
@RADoctor retrospective cohort study, shows RA at ⬆️risk severe COVID-19 outcomes than general population. PsA not at⬆️risk. Abstr#0088 #ACR21 @RheumNow https://t.co/yZ1O5JDJgq
Richard Conway @RichardPAConway ( View Tweet )
4 years 9 months ago
#ACR21 @RheumNow
Abst#0364 by Wetterslev et al. sought to identify axSpA characteristics of patients tapered off TNFI and showed clinical and radiographic improvement.
🔽52% were tapered off
⭐️The highest predictor of success is a low physician global VAS score
swethaann23 @swethaann23 ( View Tweet )
4 years 9 months ago
Dr. Rovin at #ACR21 Great Debate:
▶️ Disagrees with Dr. Petri that GFR changes are caused by hemodynamics and is temporary, and non-nephrotoxic
▶️ Voclosporin + MMF is safe
@Rheumnow https://t.co/TxDyprnZ5u
Eric Dein @ericdeinmd ( View Tweet )
4 years 9 months ago
Freq & severity of adverse events after #SARSCoV2 #vaccine in patients with autoimmune disease vs controls Abs#0104 #ACR21
•No incr. risk of AEs in autoimmune disease vs controls
•Minimal impact of vaccines on disease activity
@RheumNow
https://t.co/jGXP5UL4LP https://t.co/980NLWQYeX
Mrinalini Dey @DrMiniDey ( View Tweet )
4 years 9 months ago
FAERS data of potential rheumatic irAEs:
'Arthralgia' consistently top of the list - readily underreported, causality unclear, hard to know what it is
This is why there's only a limited amount we can learn about rheumatic irAEs without dedicated study
#ACR21 ABST0438 @RheumNow https://t.co/8HElxUZS8n
David Liew @drdavidliew ( View Tweet )
4 years 9 months ago
#ACR21 #GreatDebate: Dr. Rovin argues for VCS add to MMF b/c:
👉fewer side effects than legacy CNI
👉elevated in creatinine related hemodynamic reversible effect
👉did increase BP (but controllable)
@rheumnow (2/2) https://t.co/mmWp0sBveT
TheDaoIndex @KDAO2011 ( View Tweet )
4 years 9 months ago
#ACR21 #GreatDebate: Dr. Rovin argues for VCS add to MMF b/c:
👉improvement in complete renal response
👉rapid proteinuria resolution (in days!)
👉protect podocytes➡️protecting glomeruli➡️protect GFR
👉effective in black patients.
👉rapid steroid taper
@rheumnow (1/2)
TheDaoIndex @KDAO2011 ( View Tweet )
4 years 9 months ago
Dr Rovin: How do calcineurin inhibitors protect podoctyes?
👉by protecting synaptopodin (critical for stabilizing the actin cytoskeleton)
👉also by reducing podocyte apoptosis
@RheumNow #ACR21 #lupus #MedTwitter https://t.co/QZTwiT5Hd7
sheila @RHEUMarampa ( View Tweet )
4 years 9 months ago
