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Costs of #JIA are substantial, total costs up to 44,832 USD annually. Direct costs up to $32,446 USD, accounting for 55-98 % of total. $$$ mostly related to meds; cost go up 3 fold after biologic initiation. (JIA Indirect costs are underrepresented) https://t.co/rukJPWqD0y
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Dr. John Cush @RheumNow ( View Tweet )
4 years 9 months ago
Are you registered on the #RheumNow site? With registration, you’ll receive new daily content first and can sign up for topic specific emails.
https://t.co/riyAnrRHhX
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Dr. John Cush @RheumNow ( View Tweet )
4 years 9 months ago
Start #MTX & escalate 5mg q2wk (usual) or 5mg q4wk (fast): open RCT 178 #RA pts - equal EULAR resp (28 v 23%), DAS28-CRP (-1.3 v -1.3) - same at wk8 & 24. No diff in MTX polygluts., cell #s, LFTs, D/C - but more GI sx w/ fast wk8 (40 vs 27%) https://t.co/MbuFoA5HFp
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Dr. John Cush @RheumNow ( View Tweet )
4 years 9 months ago
Metanalysis of NSAIDs & opioids in Knee/Hip #OA - 192 RCTs (102829 pts). AE dropouts & adverse events were ZERO w/ topical NSAIDs; highest w/ opioids (83% & 90%). Pronounced Rx benefit more likely w/ oral & topical NSAIDs (99 & 93% probability) https://t.co/376uAzMcpH
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Dr. John Cush @RheumNow ( View Tweet )
4 years 9 months ago
US Preventive ServTask Force has advised that adults >60 yrs should NOT take daily preventative aspirin without a no hx of MI/CVD risk (the GI risks outweigh CV benefit). If 40-59 yrs, discuss w/ their MD if ASA would be beneficial https://t.co/jfqnBjwLLn
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Dr. John Cush @RheumNow ( View Tweet )
4 years 9 months ago
FDA Approves Avacopan for ANCA-Associated Vasculitis
https://t.co/L7UwhYBaVY
#RheumNow https://t.co/0cGN5eyfCl
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Dr. John Cush @RheumNow ( View Tweet )
4 years 9 months ago
Triple DMARD Rx - MSH vs MLH (Lef). 136 active #RA pts given OL MTX/SSZ/HCQ vs MTX/HCQ/LEF. Equal efficacy (EULAR-Good) was seen at wk 12 (54% vs 59%) and wk 24 (65% vs 62%) - hence LEF substitution was noninferior. https://t.co/F5CGj0w7Bh
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Dr. John Cush @RheumNow ( View Tweet )
4 years 9 months ago
RETRO - Taper or Not: You Decide
A prospective, phase 3 trial of RA patients in sustained remission has shown more than half will flare if DMARD therapy is tapered or discontinued and that remission is best maintained by continued DMARD therapy.
https://t.co/KDqGrujGMT https://t.co/8HqSS74PqL
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Dr. John Cush @RheumNow ( View Tweet )
4 years 9 months ago
Anakinra appears to lower mortality risk (OR 0·32 vs historic controls) in hospitalized severe COVID-19 pneumonia (esp w/ hyperinflammation, CRP >100 mg/L). Metanalysis of nearly 2000 pts; better resp if given w/ dexamethasone (OR 0·23) https://t.co/7nFAkLgpGK
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Dr. John Cush @RheumNow ( View Tweet )
4 years 9 months ago
Diagnositic Imaging comparison in 36 acute Gout vs CPPD pts:
- Better: MSK US sensitivity/specificity for gout 92%/83% & 91%/92% for CPPD
- Less: DECT sensitivity/specificity for gout 63%/92% & 55%/92% for acute CPPD https://t.co/Ee2MFb8qyl
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Dr. John Cush @RheumNow ( View Tweet )
4 years 9 months ago
Low dose #methotrexate in primary cardiac prevention #CIRT. Trial had LESS decline in GFR in those with mild renal impairment than placebo. ?meaningful or a fluke. Either way MTX can be used safely in mild CRF! Just follow creatinine/GFR. #ClinicalPearl @RheumNow https://t.co/SyfsxZEeUH
Janet Pope @Janetbirdope ( View Tweet )
4 years 9 months ago
As a loud, fast talking man that has no idea what he’s talking about, I can vouch for this. https://t.co/0pjuzHhEBK
Ethan Craig @rheumecraig ( View Tweet )
4 years 9 months ago
