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Gout does occur with low SUA levels; Using data from ARIC, Framingham and CARDIA studies, the gout risk over 15 yrs was:
SUA < 4 = 0.59%
4–4.49 = 1.28%
4.5–4.99 = 0.86%
5–5.49 = 0.94%
5.5–5.99 = 1.52%
6–6.49 = 2.91%
6.50–6.99 = 3.2%
> 7.00 = 12.2%
https://t.co/xm9iQrQT3U https://t.co/lVOTl18GK6
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Dr. John Cush @RheumNow ( View Tweet )
4 years 11 months ago
Metanalysis of long-term steroid (GC) in PMR (24 studies) 77%, 51%, & 25% PMR pts still GC respectively 1, 2, & 5 yrs. 1st Yr pooled relapse rate =43%. Prolonged GC use/relapse moreso in Females, Hi ESR, periph arthritis, starting dose, tapering speed https://t.co/n0gGlik1hO https://t.co/WBqdfUW2RS
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Dr. John Cush @RheumNow ( View Tweet )
4 years 11 months ago
Multi-center study of 215 pediatric SLE patients - 55%(118) w/ Hematologic findings: most common anemia (88), hemolytic anemia (4). Signif assoc w/ HEME dz: Renal Dz, low C3, APL Abs, anti-β2 GP1, Sm, LAC, high SLEDAI. Most Rx w/ steroids, IVIG or RTX https://t.co/nuD524kkD4 https://t.co/6a14bQ6SQ6
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Dr. John Cush @RheumNow ( View Tweet )
4 years 11 months ago
Watch: Drs. Jack Cush, Kathryn Dao ( @KDAO2011) , Janet Pope ( @Janetbirdope) Eric Dein ( @ericdeinmd) and Yuz Yusof discuss a number of lupus presentations presented at the virtual EULAR 2021 meeting. #RheumNow
https://t.co/yUEXTOatpR
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Dr. John Cush @RheumNow ( View Tweet )
4 years 11 months ago
Tumor necrosis factor inhibitors (TNFi) are frequently used first line in rheumatoid arthritis (RA) patients; and a new analysis shows that repeat use of TNFi dominates over the use of non-TNFi biologics when the initial TNFi therapy has failed.
https://t.co/hmFZKrMdJ1 https://t.co/whCPvAAMMi
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Dr. John Cush @RheumNow ( View Tweet )
4 years 11 months ago
Octave study examined COVID-19 Vax Ab responses in 600 immunocompromised-IMC (Cancer, IMID) pts. Compared to normals, fewer IMC seroconverted @4 wks (89 vs 100%). 40% of IMC had a low Ab resp; 11% of IMC had zero Ab response https://t.co/11VkeNKzvL
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Dr. John Cush @RheumNow ( View Tweet )
4 years 11 months ago
Gut microbiome strongly influences irAE's in advanced melanoma pts taking checkpoint blockade targeting CTLA-4 and PD-1. Signatures for Bacteroides intestinalis & Intestinibacter bartlettii more grade 3+ irAE by inducing IL-1B https://t.co/rEHknJ3TSC
Dr. John Cush @RheumNow ( View Tweet )
4 years 11 months ago
NIAID will study COVID‐19 Booster Vaccine in Autoimmune Disease Non‐Responders (including MS, RA, SLE, Scleroderma,pemphigus); 20 sites, 600 pts (taking MTX, MMF or RTX) w/ poor resp to mRNA vax & recv 3rd booster vax. https://t.co/YwCvGnX21F https://t.co/th2WoRv1ng
Dr. John Cush @RheumNow ( View Tweet )
4 years 11 months ago
Large US Behcets disease registry in USA: 1023 pts w/ more women (79%) than expected. Most frequently Meds: steroids (68%), colchicine-COL (55%), MTX (22%), TNFi (29%); only 3.2% apremilast. Less COL, CsA, CTX vs use in Egypt/Turkey/Iran https://t.co/hpHO6C8LKW
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Dr. John Cush @RheumNow ( View Tweet )
4 years 11 months ago
JCI paper showing IgG fibromyalgia pts given to mice leads to passive transfer of FM symptoms leads to sensory hypersensitivity; increased sensitivity to noxious mechanical & cold stimulation, & nociceptive fibers in skin-nerve preparations.WHAT? https://t.co/af24a9BzzW
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Dr. John Cush @RheumNow ( View Tweet )
4 years 11 months ago
New podcast available--Dr. Jack Cush reviews the news, journal reports and cautions regarding COVID-19.
https://t.co/rugwkPb8KQ https://t.co/dCCzlemjfu
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Dr. John Cush @RheumNow ( View Tweet )
4 years 11 months ago
We've got another resource available on Cytokine Storm Management. Log in and download today.
https://t.co/dTAzMVa6SB https://t.co/BvsZFxGrQl
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Dr. John Cush @RheumNow ( View Tweet )
4 years 11 months ago
