Tweets
New study data on mRNA vaccines in pts with inflammatory diseases on mostly #TNFi +/- #csDMARDs .
▶️ Effective immune response (lower than healthy controls)
▶️Comparable side effects
▶️ no ⬆️ in DAS28
▶️ no pts on #Rituximab included
https://t.co/aexdFoUzer https://t.co/h1S1S2YsHS
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ARD & RMD Open @ARD_BMJ ( View Tweet )
4 years 11 months ago
Biomarkers predict early ILD in systemic sclerosis: https://t.co/9z4Swjjy4p we need a biomarker for early disease!
Peter Nash @drpnash ( View Tweet )
4 years 11 months ago
Chronologic Progression of Ankylosing Spondylitis
https://t.co/ihVVystOMn https://t.co/SXhkkBgzTJ
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Dr. John Cush @RheumNow ( View Tweet )
4 years 11 months ago
COVID Vaccine Booster Effective for Transplant Recipients in Small Trial
For organ transplant recipients, a third dose of Moderna's COVID-19 vaccine more than tripled the proportion with a sufficient antibody response, a randomized trial showed.
https://t.co/iD2WFfUP3a https://t.co/eYMdocd9T4
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Dr. John Cush @RheumNow ( View Tweet )
4 years 11 months ago
A new European real world experience study shows that mepolizumab is effective at both 100 or 300mg every 4 weeks in patients with the rarely encountered eosinophilic granulomatosis with polyangiitis (EGPA; or Churg-Strauss Syndrome).
https://t.co/hgeiSHhxSj https://t.co/cfi2nZGzBa
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Dr. John Cush @RheumNow ( View Tweet )
4 years 11 months ago
Symptom eval of 870 1st degree relatives of RA in PREVeNT-RA study - 5% were seropositive & 14% had incr CRP. Sleep probs (20%) & joint pain (18%) most common. Symmetrical small joint pain ~12% higher in RF+ and 11% higher w/ high CRP https://t.co/aYoLX0sZ2p
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Dr. John Cush @RheumNow ( View Tweet )
4 years 11 months ago
Interesting case report of difficult periorbital Discoid lupus erythematosus (DLE) treated with topical tofacitinib, 2%, ointment, a topical Janus kinase (JAK) 1/3 inhibitor. https://t.co/NZxUFW9ilN
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Dr. John Cush @RheumNow ( View Tweet )
4 years 11 months ago
Drs. Jack Cush, Kathryn Dao, Janet Pope, Eric Dein and Yuz Yusof discuss a number of lupus presentations as well as abstracts presented at the virtual EULAR 2021 meeting. Lupus nephritis and treat-to-remission presentations were discussed by the panel.
https://t.co/dfRdeveeLp
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Dr. John Cush @RheumNow ( View Tweet )
4 years 11 months ago
85 rheumatic kids RTX treated - New hypogammaglobulinemia in 27% w/in 18 mos AND 26% w/ infections (half being serious infx). Prior pulse steriods ups risk of inx (OR 15.3) and hypogamma (OR 3.9). Hypogamm predicts risk of SIE (OR 7.9)
Dr. John Cush @RheumNow ( View Tweet )
4 years 11 months ago
In 206 #SLE pts (mean 62 yrs) polypharmacy (≥10 meds) seen in 35%. 31% used benzodiazepines & 24% opioids. Polypharmacy greater with prednisone, comorbidity & rural. Polypharmacy assoc w/ 4X Benzo & 7X opioid use https://t.co/4U0UakoIRr
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Dr. John Cush @RheumNow ( View Tweet )
4 years 11 months ago
Takayasu's responds to Tofacitinib - 53 pts given TOF + glucocorticoids (GCs) (n=27) or MTX + GCs (n=26). At 12 mos complete remission (CR) more with TOF (88% vs 56%, p=0.02), w/ lower GC use and relapse rates ((12% vs 35%, p=0.052) https://t.co/qgziyIhKgV
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Dr. John Cush @RheumNow ( View Tweet )
4 years 11 months ago
Current Israel data for mRNA vaccination in people age >60, 1st to get vaccines >6 months ago, now confronting Delta infections
1. Vaccines work but their apparent effectiveness is diminished over time + Delta
2. Boosters showing some preliminary evidence of working
via @dvir_a https://t.co/YKgF9dlFz3
Eric Topol @EricTopol ( View Tweet )
5 years ago
