Tweets
Literature review examined safety of IL-17 inhibitors in 106 controlled RCTs, 40,053 pts. Inflammatory bowel disease was reported in 0.4% of IL-17i Rx patients. (same in 61 uncontrolled RCTs -0.36%). Other AE: diarrhea (2.5%), N/V(0.7%) https://t.co/2wSZQqB1Zs
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Dr. John Cush @RheumNow ( View Tweet )
5 years ago
JAMA article on using new features in Updated PubMed:
1) Focus the Clinical Question
2) Use PubMed Clinical Query Filters
3) Refine the Search Terms
https://t.co/ExK8p2hVnX
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Dr. John Cush @RheumNow ( View Tweet )
5 years ago
Comparison of 1040 elderly-onset RA (EORA) and 710 non-EORA patients showed similar disease activity, DMARD choices, drug response rates and reasons for Rx discontinuation - There's no reason EORA shouldn't be treated as aggressive as all RA! https://t.co/P2gpPlJVZE
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Dr. John Cush @RheumNow ( View Tweet )
5 years ago
ICYMI:
Drugs capable of inducing drug-associated ANCA vasculitis - mirabegron (Myrbetriq), sofosbuvir (Sovaldi, antiviral), nintedanib (Ofev), hydralazine, propylthiouracil, thiamazole, minocycline, carbimazole, allopurinol, influenza vax.... https://t.co/KhK2w0IGAx
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Dr. John Cush @RheumNow ( View Tweet )
5 years ago
Health personnel (HCP) @ long-term care facilities (LTCFs) are at high risk for COVID-19. March 2021, 57% of LTCF HCPs were vaccinated. COVID-19 vax was highest in MDs (75.1%); lowest nurses (56.7%) & aides (45.6%). https://t.co/VjHutcrh26
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Dr. John Cush @RheumNow ( View Tweet )
5 years ago
The FDA has authorized baricitinib ALONE as treatment for COVID-19 hospitalized adults and pediatric patients requiring supplemental oxygen, non-invasive or invasive mechanical ventilation, or extracorporeal membrane oxygenation (ECMO) https://t.co/WMc78GmOLU
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Dr. John Cush @RheumNow ( View Tweet )
5 years ago
What predicts ILD progression in Systemic Sclerosis? Study of 138 SSc pts; 72% had ILD, 35% FVC decline (F/U 2.9y). Only Scl-70 A positivity predicted FVC decline at 5yrs. HRCT Esophageal dilation had nonsignificant DLCO decline, but not FVC https://t.co/fE0JCsZ44O
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Dr. John Cush @RheumNow ( View Tweet )
5 years ago
ICYMI:
EULAR guidelines rec starting prednisone dose in #PMR to be between 12.5-25mg/d. A cross sectional study of 138 pts (63M, 75F, age 73.4 yes) saw the mean starting dose to be 19.2±7.7 mg. https://t.co/Yf3yqRRMCK
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Dr. John Cush @RheumNow ( View Tweet )
5 years ago
ICYMI
While myeloperoxidase (MPO) Abs are seen in idiopathic pulmonary fibrosis (IPF), only 7–23% develop vasculitis. Study of 58 pts w/ IPF & MPO Abs - UIP most frequent ILD pattern, 13 had rheumatic dz; MPO Abs did not change survival of UIP/IPF pts https://t.co/RXXIPUBMBT https://t.co/sJpbzIbBJt
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Dr. John Cush @RheumNow ( View Tweet )
5 years ago
Big news! You can download/listen to the RheumNow podcast in more places than ever! Find us on Apple and Google podcasts, the PodBean app, Spotify, Pandora, TuneIn+Alexa, iHeart Radio, PlayerFM, Listen Notes, Stitcher, Overcast, Pocket Cast, Castro, Castbox, and Soundcloud! https://t.co/1WSUh06jjN
Dr. John Cush @RheumNow ( View Tweet )
5 years ago
Persistence of Sxs & Labs long after COVID. German study of 96 postCOVID pts followed 12 mos only 22% were Sx-free; Most had fatigue (53%), dyspnea (37%), concentration (40%), CNS (32%) & sleeping problems (26%), +ANA ≥1:160 in 44% https://t.co/L2ZzniDT18
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Dr. John Cush @RheumNow ( View Tweet )
5 years ago
204 pts w/ dermatomyositis/polymyositis Rx w/ IV early pulse steroids(IVMP) or IVIG. IVMP & IVMP+IVIG was assoc w/ 56-58% incr odds of complete response. Pulse IVMP+IVIG incr risk of steroid D/C. Early IVMP/IVIG=no impact on mortality https://t.co/yRFJgos8Qq
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Dr. John Cush @RheumNow ( View Tweet )
5 years ago
