Deep learning for SLE #POS0351 👉use of AI to ID potential targets/dz pathways 👉gene ranked using metric expression & interactivity 👉many IFN and JAK/STAT genes ranked high 👉strong assc w/new pathways related to CD4+Tcell different'n, macs, denditric cells #EULAR2021 @rheumnow https://t.co/JF7NFeX4E7

Not an expert in capillaroscopy? Not an issue! https://t.co/jHNKDtafQC: an automatic image reading system able to detect: -Normal capillaries Se 79.8% Spe 82% -Megacapillaries Se 89.4% Spe 78.8% -Hemorrhages (Se 71% She 73.9%) compared to expert #POS0256 #EULAR2021 @Rheumnow https://t.co/MR8enBO0de

Wait, let me scan your joints first! Early arthritis clinics: US examination prior first clinical review in cohort of 163: ⬇️ ⭐️time to diag from mean 31 days to 12 ⭐️n° of clinical visits - 114 visits over a year ⭐️n° of revised diag at 1yr 5 vs 16% #POS0260 #EULAR2021 @Rheumnow https://t.co/CLkNqZUJVQ

Subclinical US enthesitis in 174 IBD patients w/ or w/out PSO: -High prevalence of structural damage ≥1 enthesis 83.4% -≥1 active enthesitis 25% in IBD + PSO: -⬆️ ≥ 1 thickened enthesis 86% vs 64% p=0.009) -⬆️of PD signal at knee examination. #POS0265 @RheumNow #EULAR2021 https://t.co/8f7G5ku1kc

ESPOIR cohort 598 patients w/ EVA fatigue for 10yrs: 3 fatigue trajectories high, moderate and low, consistent over time. Predictors of high fatigue trajectory: female gender, pain, psychological distress, presence of sicca symptoms. Effect of tmts? @Rheumnow #EULAR2021 #POS0308 https://t.co/iMLKFPikaR

Depression is not only associated with high PGA but also with inflammatory markers in RA! Cross-sectional study of 258 patients: Depression (PHQ-9>10) associated with DAS28-ESR OR 1.1, DAS28 CRP OR 1.1, PGA AND CRP OR1.3 in multivariate analysis. @Rheumnow #POS0312 #EULAR2021 https://t.co/66CaqLp61r

Is genetic of RA remission different? Neither genetic risk score comprising RA susceptibility variants (OR 0.99 0.94-1.03) nor HLA-SE (OR 0.8 0.75-1.01) are associated with DAS28CRP<2.6 at 6 month in this MA of 8 inception cohorts (4425 patients) @RheumNow #EULAR21 POS0348 https://t.co/rvGovxTlRo

In a new scientific era dominated by high throughput technologies, statistical analysis is at least as important than samples quality. Different data modeling strategies applicable to ScRNASeq discussed by Dr @YvanSaeys in the #EULAR2021 Investigative Rheumatology. @Rheumnow https://t.co/eMcNfWIxM2

EUSTAR database: in 474 patients w/ no baseline ILD, t0 DLCO value<80% predicted ILD on HRCT at 2years w/ OR 3.1 [1.49-6.40]p=0.0023 while t0 FVC value<80% didn't reach statistical significance OR 1.95 p=0.13. To be confirmed in prospective studies! @RheumNow #EULAR2021 #POS0317 https://t.co/haNlN0OfX4

COVAX Registry: 1519 patients w/ 51% IA, 45% CsDMARDs, 36% bioDMARDs, 31% GCs; vaccinated with Pfizer, AZ or Moderna. Overall, very reassuring safety profile. 5% flares. Efficacy to trigger AB response needs to be further assessed. @pedrommcmachado #LB0004 @Rheumnow #EULAR2021 https://t.co/1dSfOJALzf