Tweets
Osteoarthritis Iniative study of 3053 #OA pts shows worsening in health related quality of life is most rapid with Female gender, higher BMI, smoking, knee pain, and lower income at baseline. Rapid progressors had higher risk of TKR (HR 6.2;CI 3.6–10.7) https://t.co/73OlM7ymH6
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Dr. John Cush @RheumNow ( View Tweet )
7 years ago
The RheumNow Podcast is up! "Tricked Up Lupus Criteria" and more on gout & ULT, IVIG in ANCA vasculitis, NO SIE risk w/ TNFi, and the Best 1st Biologic. Watch the video here>> https://t.co/j1Axn36hL0 or listen to the Podcast on iTUNEs or SoundCloud here>> https://t.co/rjAQmxHce6
Dr. John Cush @RheumNow ( View Tweet )
7 years ago
Amgen wins U.S. patent battle against Novartis over Enbrel patents, delaying Novartis' attempts to launch its etanercept biosimilar Erelzi until (possibly) 2029. Novartis intends to appeal. https://t.co/uoEQJJUf9A
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Dr. John Cush @RheumNow ( View Tweet )
7 years ago
Medicare (CMS) has made a decision to cover expensive cancer cell therapies - especially CAR-T therapy - costs re $373,000 for a one-time treatment before hospital costs. https://t.co/M4tkuVt3Gm
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Dr. John Cush @RheumNow ( View Tweet )
7 years ago
Check out the "WAR on RA - Part 3: Useless Drugs". We use to have useless drugs (gold, PCM, SSZ, HCQ) but now live in an era of biologics, combinations, JAKs - are these the answer? Watch here>> https://t.co/5wLDOofjTq or Listen on iTunes or SoundCloud https://t.co/SfPQ1sBlRI
Dr. John Cush @RheumNow ( View Tweet )
7 years ago
IL-16 studied in Scleroderma: incr perivasc IL-16 lymphocyte expression w/ more IL-16+ cells in dcSSc vs lcSSc (44 vs 29%, P<0.05). Serum IL-16 levels elevated in SSc pts (297 vs 195 pg/ml) & IL-16 correlated w/ dcSSc, skin score, erythema & pigmentation. https://t.co/lC4nRO6AH0
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Dr. John Cush @RheumNow ( View Tweet )
7 years ago
Metanalysis of Early #RA therapy (22 RCTs, 9934 pts), shows that MTX + TNF or non-TNF biologics reduces disease activity and improves remission when compared with MTX monotherapy. 20-57% higher ACR50 rates with Combination Rx https://t.co/iJKmK6uVgg
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Dr. John Cush @RheumNow ( View Tweet )
7 years ago
Internet based study by Choi et al - looked at 517 gout patients and examined if gout flares were associated with vaccination. They found a twofold higher odds of gout flare (adjusted OR 1.99; 95% CI 1.01 to 3.89 in those who were vaccinated (any vaccine). https://t.co/8zLSt3YVZF
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Dr. John Cush @RheumNow ( View Tweet )
7 years ago
Patients w/ pain, fatigue & myalgias should be #FM; but rarely could be Macrophagic myofasciitis -- rare myopathy manifest as "algias", weakness, fatigue, fever, & muscle tenderness. Dx by biopsy of vaccinated muscle showing PAS+ macrophages w/ aluminum https://t.co/9Ll4pE3wXJ
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Dr. John Cush @RheumNow ( View Tweet )
7 years ago
Check out Part 3 - War on RA - "Useless Drugs" This one is why we need more than our best new drugs to deliver us from the evil of #RA. Rear it, Watchit, Listen to it Here >> https://t.co/5wLDOnXJ1S
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Dr. John Cush @RheumNow ( View Tweet )
7 years ago
Prospective study of 83 gout patients; 77 on urate lowering Rx, 6 discontinued Rx. The D/C group had no change in MSU deposits or SUA levels, In the ULT group MSU burden significantly decreased (MSU volume: p=0.007) and sUA dropped from 7.2 to 5,8 mg/dl. https://t.co/YfXjTKz1va
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Dr. John Cush @RheumNow ( View Tweet )
7 years ago
PLoS reports that a study of 10,059 men from Israel were followed serially showing that higher variability in serum Uric Acid levels over 5 years was clearly predictive of 18-year Coronary heart disease and all-cause mortality. https://t.co/bDqI32aVXt
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Dr. John Cush @RheumNow ( View Tweet )
7 years ago
NHANES 30 yr study of 58,731 shows prevalence of of chr hepatitis B & alcoholic liver dz stable; chronic hepatitis C decreased twofold; but non-alcoholic fatty liver dz (NAFLD) has increased from 20% to 32%; with a parallel increase in obesity & NIDDM https://t.co/6vxFLUBhEd
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Dr. John Cush @RheumNow ( View Tweet )
7 years ago
Metanalysis of 9 studies shows that use of IVIG in ANCA-Associated vasculitis is assoc. w/ significant and rapid improvement in BVAS (SMD –1.7), ANCA (SMD –0.72) and CRP (SMD –0.92) within 2-24 weeks. https://t.co/aw3VjBWCcf
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Dr. John Cush @RheumNow ( View Tweet )
7 years ago
FDA has approved Turalio (pexidartinib) for the treatment of adults with the rare disorder, tenosynovial giant cell tumor (TGCT) associated with severe morbidity or functional limitations and not responsive to improvement with surgery. https://t.co/eMTmFSW97A
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Dr. John Cush @RheumNow ( View Tweet )
7 years ago
