27yoF w/ chronic 4 mos b/l knee effusions (SF WBC=22K, -C/S), MRI synovitis only, Labs normal but with +ANA 1:160, neg Parvo, B27, RF, CCP, RPR, HCV/HBV, ESR and CRP. No resp to NSAIDs or IA steroids. DX?

28 yr old w/ nail pitting on both hands. Other signs of nail psoriasis are yellow/ pink ("oil-drop") discoloration, onycholysis, subungual hyperkeratosis, nail plate crumbling, splinter hemorrhages. 3 other diseases cause nail pitting -which ones? https://t.co/B38TE1MYW0

Statin Safety review from the American Heart Assn says 1 in 4 adults > 40yrs takes a statin; lowering LDL by 55-60%. Statin-induced rhabdomyolysis is <0.1%, and serious hepatotoxicity is ≈0.001%. The risk of statin-induced new diabetes is ≈0.2%/Year https://t.co/1FLZFsvmvZ

Acute onset 1st MTP swelling and Pain w/ ultrasound evidence of synovitis on power doppler - the most likely diagnosis is? https://t.co/VGkxLR7aRh

Vasculitis may complicate autoinflammatory Dz - in FMF (IgA vasculitis, PAN), vasculitis may occur w/ CAPS, TRAPS, HIDS, DIRA, PAPA & Behcets syndromes. Vasculitis is part of DAD2 deficiency (STING-assoc vasculopathy w/ onset in infancy-SAVI (PAN-like) https://t.co/7MKo05pOa3

Systematic review of 41 papers shows that polymyalgia rheumatica is associated with comorbidities - CVA, CAD, peripheral arterial disease, diverticular disease, hypothyroidism, but there is disagreement as to an association betw PMR and cancer. https://t.co/74rwKuixR8

Registry studies of systemic sclerosis shows that early severe GI involvement (9% at 2yrs) is associated with increase risk of inflammatory myositis (OR 4.68), telangiectasias (OR 2.45), skin progression and a >2-fold risk of death (HR 2.27) https://t.co/6e96TldL2S

Pfizer intends to do a phase 3 study of tofacitinib 5 mg bid (vs PBO) in adults with active ankylosing spondylitis ~ 240 pts in a multinational study. Previously a 16 week, phase 2 trial showed an 82% ASAS20 response in AS pts. https://t.co/u1I0Tpdtl6

Galectin-9 is a biomarker correlating with type 1 IFN signature and correlates w/ disease activity in SLE and and antiphospholipid syndrome and may also correlate with other autoimmune Dz - Sjögren’s, systemic sclerosis & juvenile) dermatomyositis https://t.co/TfpwMAIaaI

The Best Rheums go to the Best Meetings - RHEUMNOW LIVE - March 22-24 2019 Great Venue =Fort Worth. Short Lectures, interactive sessions, Q&A panels, TED (like) Talks, digital, streaming and much more. You dont want to miss this meeting! https://t.co/5TVg0Frsbf

Bipartisan senators introduce new drug pricing bill https://t.co/mDWxPEtHhz

J. Hopkins study of 27 pts with inflammatory arthritis due to immune checkpoint inhibitors (mostly European ancestry) shows higher rate (61.5%) of at least 1 Shared Epitope allele (similar to RA pts) but were more likely to be seronegative for RF or CCP https://t.co/uR7ESZ2s07