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Clinical Expectations of Biosimilars is one of several educational videos available in the "Therapeutic Update: Biosimilars in Rheumatology" video series, sponsored by Sandoz, Inc. and now available on RheumNow. https://t.co/1vmnEJqOSi
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Dr. John Cush @RheumNow ( View Tweet )
7 years 8 months ago
Musculoskeletal/Rheumatic diseases (arthralgias, myalgias, arthritis, PMR, myositis, Sjogrens, SLE) are uncommon side effects of immune checkpoint inhibitors, so-called irAE (immune related adverse events). Good review here. https://t.co/R52SW0HUjv
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Dr. John Cush @RheumNow ( View Tweet )
7 years 8 months ago
Despite many excellent therapies, most patients with gout are not adequately managed, and patients and providers have many misconceptions about gout. Great review by Ted Fields, MD https://t.co/Njpo1225XP
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Dr. John Cush @RheumNow ( View Tweet )
7 years 8 months ago
Bisphosphonate safety review - risk of Atypical Femoral Fracture is 1/1000 and risk of osteonecrosis of the jaw is 1/10,000. One-third of IV zolendronic acid pts will have arthralgia/myalgias or flu like sxs. https://t.co/80xBkZlKgn
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Dr. John Cush @RheumNow ( View Tweet )
7 years 8 months ago
TB Testing 2
- Note: <10% of pts initially PPD/IGRA neg may be positive later (either they were anergic or have a new TB infx). I Recommend repeat TB testing 3 mos after starting or changing from 1st to 2nd biologic
- Repeat testing indicated if newly EXPOSED or when Risk Changes
Dr. John Cush @RheumNow ( View Tweet )
7 years 8 months ago
TB Testing
- Do PPD or IGRA before TNFi or biologic
- If negative, start therapy
- If Positive, Eval for active TB (Sxs, CXR, C/S); if neg --> LTBI Rx BEFORE biologic
- If "Indeterminate", repeat or change test. If same or neg--> start biologic
- Do not do annual TST or IGRA
Dr. John Cush @RheumNow ( View Tweet )
7 years 8 months ago
Metanalysis shows DMARDs (6 studies) and biologics (5 studies) offer NO clinically significant benefit compared with placebo in Osteoarthritis. https://t.co/fNGVzuNQNo
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Dr. John Cush @RheumNow ( View Tweet )
7 years 8 months ago
Vasculopathy (inflammatory, occlusive, necrotizing) distguishes juvenile dermatomyositis from adult myositis - also w/ high risk of severe extra-muscular dz (GI, Lung, cardiac, skin). Good review article here https://t.co/yH8xwKl6S8
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Dr. John Cush @RheumNow ( View Tweet )
7 years 8 months ago
Could routine use of hydroxychloroquine reduce the rate of serious infections in immunosuppressed patients? A modest to moderate risk reduction noted in two large SLE cohort studies. https://t.co/pssLrteRRq
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Dr. John Cush @RheumNow ( View Tweet )
7 years 8 months ago
2018 NRMP report shows Rheumatology as one of the most competitive fellowships with 313 applicants for 221 positions - 147 filled by US grads and 69 by FMGs. https://t.co/xRmMyA2yCy
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Dr. John Cush @RheumNow ( View Tweet )
7 years 8 months ago
Clinical Trials Benchmark for Biosimilar Development is one of several educational videos available in the "Therapeutic Update: Biosimilars in Rheumatology" video series, sponsored by Sandoz, Inc. and now available on RheumNow. https://t.co/1vmnEJqOSi
Links:
Dr. John Cush @RheumNow ( View Tweet )
7 years 8 months ago
J Rheum (Ward et al) reports that the minimal clinically important improvement (MCII) of RAPID-3 was –3.8. https://t.co/UxCOeMl52g
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Dr. John Cush @RheumNow ( View Tweet )
7 years 8 months ago
The "Type" of person you are often is displayed with how you manage authority
Dr. John Cush @RheumNow ( View Tweet )
7 years 8 months ago
CORRECTION: mm! Guidelines on CT pulm nodules-no F/U needed for solid nodules <6mm in low risk pts (age,smoking, morphology); but larger (6-8mm), suspicious nodules should have 6 & 12 mos F/U images. Some 8cm or more nodules require more freq assessments https://t.co/Nl6zV3VQg1
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Dr. John Cush @RheumNow ( View Tweet )
7 years 8 months ago
“This is not your responsibility but it is your problem.” — Cheryl Strayed
I believe the converse is more important to what we need to teach our patients - "This is not just your problem, this is now your responsibility"
Dr. John Cush @RheumNow ( View Tweet )
7 years 8 months ago
